Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia

MJNL Benders*, AF Bos, CMA Radernaker, M Rijken, HL Torrance, F Groenendaal, F van Bel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

83 Citations (Scopus)

Abstract

Objective: To investigate whether postnatal allopurinol would reduce free radical induced reperfusion/reoxygenation injury of the brain in severely asphyxiated neonates.

Method: In an interim analysis of a randomised, double blind, placebo controlled study, 32 severely asphyxiated infants were given allopurinol or a vehicle within four hours of birth.

Results: The analysis showed an unaltered (high) mortality and morbidity in the infants treated with allopurinol.

Conclusion: Allopurinol treatment started postnatally was too late to reduce the early reperfusion induced free radical surge. Allopurinol administration to the fetus with (imminent) hypoxia via the mother during labour may be more effective in reducing free radical induced post-asphyxial brain damage.

Original languageEnglish
Pages (from-to)F163-F165
Number of pages3
JournalARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
Volume91
Issue number3
DOIs
Publication statusPublished - May-2006

Keywords

  • HYPOXIC-ISCHEMIC ENCEPHALOPATHY
  • NEONATAL ENCEPHALOPATHY
  • ULTRASOUND
  • INFANTS
  • LESIONS
  • TRIAL

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