EARLY-STAGE YOUNG BREAST CANCER PATIENTS: IMPACT OF LOCAL TREATMENT ON SURVIVAL

Enja J. Bantema-Joppe, Linda de Munck, Otto Visser, Pax H. B. Willemse, Johannes A. Langendijk, Sabine Siesling, John H. Maduro*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Abstract

Purpose: In young women, breast-conserving therapy (BCT), i.e., lumpectomy followed by radiotherapy, has been associated with an increased risk of local recurrence. Still, there is insufficient evidence that BCT impairs survival. The aim of our study was to compare the effect of BCT with mastectomy on overall survival (OS) in young women with early-stage breast cancer.

Methods and Materials: From two Dutch regional population-based cancer registries (covering 6.2 million inhabitants) 1,453 women

Results: With a median follow-up of 9.6 years, 10-year OS was 83% after BCT and 78% after mastectomy, respectively (unadjusted hazard ratio [HR], 1.37; 95% confidence interval [CI], 1.09-1.72). In N0-patients, 10-year OS was 84% after BCT and 81% after mastectomy and local treatment was not associated with differences in OS (HR 1.19; 95% CI, 0.89-1.58; p = 0.25). Within the N1-patient group, OS was better after BCT compared with mastectomy, 79% vs. 71% at 10 years (HR 1.91; 95% CI, 1.28-2.84; p = 0.001) and in patients treated with adjuvant hormonal therapy (HR 0.34; 95% CI, 0.18-0.66; p = 0.001).

Conclusions: In this large population-based cohort of early-stage young breast cancer patients, 10-year OS was not impaired after BCT compared with mastectomy. Patients with 1 to 3 positive lymph nodes had better prognosis after BCT than after mastectomy. (C) 2011 Elsevier Inc.

Original languageEnglish
Pages (from-to)E553-E559
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume81
Issue number4
DOIs
Publication statusPublished - 15-Nov-2011

Keywords

  • Breast cancer
  • Young age
  • Breast-conserving therapy
  • Mastectomy
  • Population-based cancer registry
  • CONSERVING THERAPY
  • ADJUVANT CHEMOTHERAPY
  • EUROPEAN ORGANIZATION
  • RADICAL-MASTECTOMY
  • RANDOMIZED-TRIALS
  • POOR SURVIVAL
  • RISK-FACTORS
  • RECURRENCE
  • WOMEN
  • AGE

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