Easy Synthesis of Two Positional Isomeric Tetrazole Libraries

Yuanze Wang, Pravin Patil, Alexander Dömling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

A fast and efficient synthesis of libraries of positional isomeric 1H-tetrazoles and 5H-tetrazoles, for the purpose of testing binding hypothesis of isomeric tetrazoles in fragment-based drug discovery, is described.
Original languageEnglish
Pages (from-to)3701-3712
Number of pages12
JournalSynthesis
Volume48
Issue number21
DOIs
Publication statusPublished - Jun-2016

Keywords

  • 1 H -tetrazole
  • 5 H -tetrazole
  • cyanoacetamide
  • fragment-based drug discovery
  • isocyano acetamide
  • Oliveri-Mandala and Alagna reaction
  • [2+3] cycloaddition
  • 1 (pyrrolidin 1 yl) 2 (1h tetrazol 5 yl)ethan 1 one
  • 1 morpholino 2 (1h tetrazol 5 yl)ethan 1 one
  • 1h tetrazole
  • 2 (1h tetrazol 5 yl) n [1 (para tolyl)ethyl]acetamide
  • 2 (1h tetrazol 5 yl) n [2 (thiophen 2 yl)ethyl]acetamide
  • 2 isocyano n (1 phenylethyl)acetamide
  • 5h tetrazole
  • n (2 hydroxy 2 phenylethyl) 2 (1h tetrazol 5 yl)acetamide
  • n (2,2 diphenylethyl) 2 (1h tetrazol 5 yl)acetamide
  • n (3 phenylpropyl) 2 (1h tetrazol 5 yl)acetamide
  • n (3,4 dimethoxybenzyl) 2 (1h tetrazol 5 yl)acetamide
  • n (4 chlorobenzyl) 2 (1h tetrazol 5 yl)acetamide
  • n (4 chlorobenzyl) 2 isocyanoacetamide
  • n (4 fluorobenzyl) 2 (1h tetrazol 5 yl)acetamide
  • n (4 fluorobenzyl) 2 isocyanoacetamide
  • n (4 fluorophenethyl) 2 (1h tetrazol 5 yl)acetamide
  • n (4 phenylbutyl) 2 (1h tetrazol 5 yl)acetamide
  • n (furan 2 ylmethyl) 2 (1h tetrazol 5 yl)acetamide
  • n (naphthalen 2 ylmethyl) 2 (1h tetrazol 5 yl)acetamide
  • n [1 (4 chlorophenyl)ethyl] 2 (1h tetrazol 5 yl)acetamide
  • n allyl 2 (1h tetrazol 5 yl)acetamide
  • n benzyl 2 (1h tetrazol 5 yl)acetamide
  • n benzyl 2 isocyanoacetamide
  • n butyl 2 (1h tetrazol 5 yl)acetamide
  • n cyclohexyl 2 (1h tetrazol 5 yl)acetamide
  • n cyclopropyl 2 (1h tetrazol 5 yl)acetamide
  • n dodecyl 2 (1h tetrazol 5 yl)acetamide
  • n phenethyl 2 (1h tetrazol 5 yl)acetamide
  • tetrazole derivative
  • unclassified drug
  • unindexed drug
  • article
  • chemical binding
  • cycloaddition
  • precipitation
  • reaction time
  • substitution reaction
  • synthesis
  • temperature

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