ECNP consensus meeting. Bipolar depression. Nice, March 2007

Guy M. Goodwin*, Ian Anderson, Celso Arango, Charles L. Bowden, Chantal Henry, Philip B. Mitchell, Willem A. Nolen, Eduard Vieta, Hans-Ulrich Wittchen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

135 Citations (Scopus)

Abstract

Diagnosis and epidemiology: DSM-IV, specifically its text revision DSM-IV-TR, remains the preferred diagnostic system. When employed in general population samples, prevalence estimates of bipolar disorder are relatively consistent across studies in Europe and USA. In community studies, first onset of bipolar mood disorder is usually in the mid-teenage years and twenties, and the occurrence of a major depressive episode or hypomania is usually its first manifestation. Since reliable criteria for delineating unipolar (UP) and bipolar (BP) depression cross-sectionally are currently lacking, there is a longitudinal risk - probably over 10% - that initial UP patients ultimately turn out as BP in the longer run. Its early onset implies a severe potential burden of disease in terms of impaired social and neuropsychological development,most of which is attributable to depression.

Original languageEnglish
Pages (from-to)535-549
Number of pages15
JournalEuropean Neuropsychopharmacology
Volume18
Issue number7
DOIs
Publication statusPublished - Jul-2008

Keywords

  • bipolar depression
  • bipolar disorder
  • mania
  • antidepressants
  • mood stabilisers
  • anticonvulsants
  • antipsychotics
  • manic switch
  • clinical trials
  • COMORBIDITY SURVEY REPLICATION
  • DOUBLE-BLIND
  • NATURAL-HISTORY
  • I DISORDER
  • DIAGNOSTIC GUIDELINES
  • 12-MONTH PREVALENCE
  • SPECTRUM DISORDER
  • RATING-SCALE
  • STEP-BD
  • CHILDREN

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