Economic Analyses of Respiratory Tract Infection Diagnostics: A Systematic Review

Simon van der Pol; Paula Rojas Garcia; Maarten J Postma; Fernando Antoñanzas Villar; Antoinette D I van Asselt

doi:10.1007/s40273-021-01054-1

Economic Analyses of Respiratory Tract Infection Diagnostics: A Systematic Review

Simon van der Pol^*, Paula Rojas Garcia, Maarten J Postma, Fernando Antoñanzas Villar, Antoinette D I van Asselt

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

119 Downloads (Pure)

Abstract

BACKGROUND: Diagnostic testing for respiratory tract infections is a tool to manage the current COVID-19 pandemic, as well as the rising incidence of antimicrobial resistance. At the same time, new European regulations for market entry of in vitro diagnostics, in the form of the in vitro diagnostic regulation, may lead to more clinical evidence supporting health-economic analyses.

OBJECTIVE: The objective of this systematic review was to review the methods used in economic evaluations of applied diagnostic techniques, for all patients seeking care for infectious diseases of the respiratory tract (such as pneumonia, pulmonary tuberculosis, influenza, sinusitis, pharyngitis, sore throats and general respiratory tract infections).

METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, articles from three large databases of scientific literature were included (Scopus, Web of Science and PubMed) for the period January 2000 to May 2020.

RESULTS: A total of 70 economic analyses are included, most of which use decision tree modelling for diagnostic testing for respiratory tract infections in the community-care setting. Many studies do not incorporate a generally comparable clinical outcome in their cost-effectiveness analysis: fewer than half the studies (33/70) used generalisable outcomes such as quality-adjusted life-years. Other papers consider outcomes related to the accuracy of the test or outcomes related to the prescribed treatment. The time horizons of the studies generally are limited.

CONCLUSIONS: The methods to economically assess diagnostic tests for respiratory tract infections vary and would benefit from clear recommendations from policy makers on the assessed time horizon and outcomes used.

Original language	English
Number of pages	17
Journal	Pharmacoeconomics
DOIs	https://doi.org/10.1007/s40273-021-01054-1
Publication status	Published - 15-Jul-2021

Keywords

GUIDED ANTIBIOTIC-THERAPY
HEALTH TECHNOLOGY-ASSESSMENT
COST-EFFECTIVENESS ANALYSIS
XPERT MTB/RIF
PRIMARY-CARE
EMERGENCY-DEPARTMENT
TUBERCULOSIS DIAGNOSIS
INFLUENZA SYMPTOMS
RAPID DIAGNOSIS
MANAGEMENT

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11 Citations
2 Review article
1 Poster
1 Article

Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations
Rojas-Garcia, P., van der Pol, S., van Asselt, A. D. I., Postma, M. J., Rodriguez-Ibeas, R., Juarez-Castello, C. A., Gonzalez, M. & Antonanzas, F., Jan-2022, In: Antibiotics . 11, 1, 15 p., 27.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
4 Citations (Scopus)

219 Downloads (Pure)
Efficiency of Diagnostic Testing for Helicobacter pylori Infections: A Systematic Review
Rojas García, P., van der Pol, S., van Asselt, A. D. I., Postma, M., Rodríguez-Ibeas, R., Juárez-Castelló, C. A., González, M. & Antoñanzas, F., 8-Jan-2021, In: Antibiotics . 10, 1, 11 p., 55.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
8 Citations (Scopus)

240 Downloads (Pure)
Health-Economic Analyses of Diagnostics: Guidance on Design and Reporting
van der Pol, S., Rojas Garcia, P., Antonanzas, F., Postma, M. J. & van Asselt, A. D. I., Dec-2021, In: Pharmacoeconomics. 39, 12, p. 1355-1363 9 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
File
8 Citations (Scopus)

112 Downloads (Pure)

1 Academic presentation

Assessing the Value of Point-of-Care Diagnostics: Economic Analyses and Appraisals
Leonard, C. (Speaker), Rojas Garcia, P. (Speaker), Pol, van der, S. (Speaker) & Feldhaus, I. (Speaker)
16-Nov-2020 → 19-Nov-2020
Activity: Talk and presentation › Academic presentation › Academic

Economic analyses of respiratory tract infection diagnostics: a systematic review
van der Pol, S. (Creator), Rojas Garcia, P. (Creator), Postma, M. (Creator), Villar, F. A. (Creator) & van Asselt, T. (Creator), University of Groningen, 16-May-2021
DOI: 10.5281/zenodo.4765619, https://github.com/UMCG-Global-Health/VALUE-Dx-systematic-review
Dataset

Cite this

@article{8e761d4982ee4cd3b6e756f49530324c,

title = "Economic Analyses of Respiratory Tract Infection Diagnostics: A Systematic Review",

abstract = "BACKGROUND: Diagnostic testing for respiratory tract infections is a tool to manage the current COVID-19 pandemic, as well as the rising incidence of antimicrobial resistance. At the same time, new European regulations for market entry of in vitro diagnostics, in the form of the in vitro diagnostic regulation, may lead to more clinical evidence supporting health-economic analyses.OBJECTIVE: The objective of this systematic review was to review the methods used in economic evaluations of applied diagnostic techniques, for all patients seeking care for infectious diseases of the respiratory tract (such as pneumonia, pulmonary tuberculosis, influenza, sinusitis, pharyngitis, sore throats and general respiratory tract infections).METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, articles from three large databases of scientific literature were included (Scopus, Web of Science and PubMed) for the period January 2000 to May 2020.RESULTS: A total of 70 economic analyses are included, most of which use decision tree modelling for diagnostic testing for respiratory tract infections in the community-care setting. Many studies do not incorporate a generally comparable clinical outcome in their cost-effectiveness analysis: fewer than half the studies (33/70) used generalisable outcomes such as quality-adjusted life-years. Other papers consider outcomes related to the accuracy of the test or outcomes related to the prescribed treatment. The time horizons of the studies generally are limited.CONCLUSIONS: The methods to economically assess diagnostic tests for respiratory tract infections vary and would benefit from clear recommendations from policy makers on the assessed time horizon and outcomes used.",

keywords = "GUIDED ANTIBIOTIC-THERAPY, HEALTH TECHNOLOGY-ASSESSMENT, COST-EFFECTIVENESS ANALYSIS, XPERT MTB/RIF, PRIMARY-CARE, EMERGENCY-DEPARTMENT, TUBERCULOSIS DIAGNOSIS, INFLUENZA SYMPTOMS, RAPID DIAGNOSIS, MANAGEMENT",

author = "{van der Pol}, Simon and Garcia, {Paula Rojas} and Postma, {Maarten J} and Villar, {Fernando Anto{\~n}anzas} and {van Asselt}, {Antoinette D I}",

note = "{\textcopyright} 2021. The Author(s).",

year = "2021",

month = jul,

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doi = "10.1007/s40273-021-01054-1",

language = "English",

journal = "Pharmacoeconomics",

issn = "1170-7690",

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TY - JOUR

T1 - Economic Analyses of Respiratory Tract Infection Diagnostics

T2 - A Systematic Review

AU - van der Pol, Simon

AU - Garcia, Paula Rojas

AU - Postma, Maarten J

AU - Villar, Fernando Antoñanzas

AU - van Asselt, Antoinette D I

PY - 2021/7/15

Y1 - 2021/7/15

N2 - BACKGROUND: Diagnostic testing for respiratory tract infections is a tool to manage the current COVID-19 pandemic, as well as the rising incidence of antimicrobial resistance. At the same time, new European regulations for market entry of in vitro diagnostics, in the form of the in vitro diagnostic regulation, may lead to more clinical evidence supporting health-economic analyses.OBJECTIVE: The objective of this systematic review was to review the methods used in economic evaluations of applied diagnostic techniques, for all patients seeking care for infectious diseases of the respiratory tract (such as pneumonia, pulmonary tuberculosis, influenza, sinusitis, pharyngitis, sore throats and general respiratory tract infections).METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, articles from three large databases of scientific literature were included (Scopus, Web of Science and PubMed) for the period January 2000 to May 2020.RESULTS: A total of 70 economic analyses are included, most of which use decision tree modelling for diagnostic testing for respiratory tract infections in the community-care setting. Many studies do not incorporate a generally comparable clinical outcome in their cost-effectiveness analysis: fewer than half the studies (33/70) used generalisable outcomes such as quality-adjusted life-years. Other papers consider outcomes related to the accuracy of the test or outcomes related to the prescribed treatment. The time horizons of the studies generally are limited.CONCLUSIONS: The methods to economically assess diagnostic tests for respiratory tract infections vary and would benefit from clear recommendations from policy makers on the assessed time horizon and outcomes used.

AB - BACKGROUND: Diagnostic testing for respiratory tract infections is a tool to manage the current COVID-19 pandemic, as well as the rising incidence of antimicrobial resistance. At the same time, new European regulations for market entry of in vitro diagnostics, in the form of the in vitro diagnostic regulation, may lead to more clinical evidence supporting health-economic analyses.OBJECTIVE: The objective of this systematic review was to review the methods used in economic evaluations of applied diagnostic techniques, for all patients seeking care for infectious diseases of the respiratory tract (such as pneumonia, pulmonary tuberculosis, influenza, sinusitis, pharyngitis, sore throats and general respiratory tract infections).METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, articles from three large databases of scientific literature were included (Scopus, Web of Science and PubMed) for the period January 2000 to May 2020.RESULTS: A total of 70 economic analyses are included, most of which use decision tree modelling for diagnostic testing for respiratory tract infections in the community-care setting. Many studies do not incorporate a generally comparable clinical outcome in their cost-effectiveness analysis: fewer than half the studies (33/70) used generalisable outcomes such as quality-adjusted life-years. Other papers consider outcomes related to the accuracy of the test or outcomes related to the prescribed treatment. The time horizons of the studies generally are limited.CONCLUSIONS: The methods to economically assess diagnostic tests for respiratory tract infections vary and would benefit from clear recommendations from policy makers on the assessed time horizon and outcomes used.

KW - GUIDED ANTIBIOTIC-THERAPY

KW - HEALTH TECHNOLOGY-ASSESSMENT

KW - COST-EFFECTIVENESS ANALYSIS

KW - XPERT MTB/RIF

KW - PRIMARY-CARE

KW - EMERGENCY-DEPARTMENT

KW - TUBERCULOSIS DIAGNOSIS

KW - INFLUENZA SYMPTOMS

KW - RAPID DIAGNOSIS

KW - MANAGEMENT

U2 - 10.1007/s40273-021-01054-1

DO - 10.1007/s40273-021-01054-1

M3 - Review article

C2 - 34263422

SN - 1170-7690

JO - Pharmacoeconomics

JF - Pharmacoeconomics

ER -

Economic Analyses of Respiratory Tract Infection Diagnostics: A Systematic Review

Abstract

Keywords

Access to Document

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Research output

Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations

Efficiency of Diagnostic Testing for Helicobacter pylori Infections: A Systematic Review

Health-Economic Analyses of Diagnostics: Guidance on Design and Reporting

Activities

Assessing the Value of Point-of-Care Diagnostics: Economic Analyses and Appraisals

Datasets

Economic analyses of respiratory tract infection diagnostics: a systematic review

Cite this