Een patiënte met leverfalen en pseudocirrose

Translated title of the contribution: A female patient with liver failure and pseudocirrhosis

Petra Hoogland, Evelien W Duiker, Jan P Pennings, Vincent E de Meijer, Hans Blokzijl*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

65 Downloads (Pure)


BACKGROUND: Acute-on-chronic liver failure encompasses an acute deterioration of liver function in patients with pre-existent cirrhosis. Sometimes the clinical picture of acute-on-chronic liver failure is misleading and may not be secondary to primary liver disease, as described in our case.

CASE DESCRIPTION: A 65-year-old woman with cirrhosis was transferred to our transplantation centre because of suspected acute-on-chronic liver failure. Given her medical history of breastcancer and suspicious laboratory results, we performed a liver biopsy. This showed diffuse metastases of mammary carcinoma. Earlier CT-scans showed features of cirrhosis without signs of malignancy: a misleading phenomenon called pseudocirrhosis.

CONCLUSION: Diffuse malignant hepatic infiltration can resemble cirrhosis and acute-on-chronic liver failure, both in clinical presentation as in imaging. Liver transplantation is contraindicated in malignant liver failure. To assure a solid indication for transplantation, a liver biopsy has to be considered, even in emergency situations.

Translated title of the contributionA female patient with liver failure and pseudocirrhosis
Original languageDutch
Article numberD5946
Number of pages6
JournalNederlands Tijdschrift voor Geneeskunde
Publication statusPublished - 4-Mar-2022

Cite this