Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial

Elske J M van Gils*, Reinier H Veenhoven, Gerwin D Rodenburg, Eelko Hak, Elisabeth A M Sanders

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    40 Citations (Scopus)

    Abstract

    Seven-valent CRM197-conjugated pneumococcal conjugate vaccine (PCV7(CRM197)) reduces both vaccine serotype nasopharyngeal colonization and vaccine serotype acute otitis media by 50-60%. However, overall pneumococcal carriage and impact on otitis media are partly offset by concomitant increase of nonvaccine serotypes. We investigated in a randomized controlled trial the impact of 2-doses and 2 + 1-doses of PCV7(CRM197) on carriage of Streptococcus pneumoniae and of other nasopharyngeal commensals and well-known otitis media pathogens, Haemophilus influenzae and Moraxella catarrhalis, in children. Nasopharyngeal swabs were collected at the age of 6 weeks and at 6, 12, 18 and 24 months. We observed high carriage rates up to 68% for S. pneumoniae, 71% for H. influenzae and 68% for M. catarrhalis at the age of 18 months. Reduced dose(CRM197) schedules induced a slight reduction in overall pneumococcal carriage but no increases in the presence of H. influenzae and M. catarrhalis. (C) 2011 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)7595-7598
    Number of pages4
    JournalVaccine
    Volume29
    Issue number44
    DOIs
    Publication statusPublished - 13-Oct-2011

    Keywords

    • Pneumococcal conjugate vaccine
    • Carriage
    • Colonization
    • Replacement
    • Otitis media
    • Haemophilus influenzae
    • Moraxella catarrhalis
    • Infants
    • ACUTE OTITIS-MEDIA
    • CHILDREN
    • IMMUNOGENICITY
    • EFFICACY
    • EMERGENCE
    • PATHOGEN
    • SAFETY

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