Effect of a second, booster, influenza vaccination on antibody responses in quiescent systemic lupus erythematosus: An open, prospective, controlled study

Albert Holvast*, Sander van Assen, Aalzen de Haan, Anke Huckriede, Cornelis A. Benne, Johanna Westra, Abraham Palache, Jan Wilschut, Cornelis Kallenberg, Marc Bijl

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)

Abstract

Objective. In SLE, a decreased antibody response on influenza vaccination has been reported. In this study, we assessed whether a booster vaccination could improve antibody responses, as determined by seroprotection rates, in SLE patients.

Methods. SLE patients (n = 52) with quiescent disease (SLEDAI = 40.

Results. Following the first vaccination, seroprotection rates and geometric mean titres (GMTs) to each vaccine strain increased in both SLE patients and controls to comparable levels. Seroprotection rates in SLE patients after the first vaccination were 86.5% to A/H1N1, 80.8% to A/H3N2 and 61.5% to the B-strain while GMTs were 92.6, 56.2 and 39.2, respectively. Overall, the booster vaccination did not lead to a further rise of seroprotection rates and GMTs in SLE patients. However, in patients not vaccinated in the previous year, GMT and seroconversion rate to A/H1N1 did rise following the booster vaccination. Both influenza vaccinations did not increase SLEDAI scores.

Conclusions. Additional value of a booster influenza vaccination in SLE is limited to patients who were not vaccinated in the previous year.

Original languageEnglish
Pages (from-to)1294-1299
Number of pages6
JournalRheumatology
Volume48
Issue number10
DOIs
Publication statusPublished - Oct-2009

Keywords

  • Systemic lupus erythematosus
  • Influenza vaccination
  • Booster vaccination
  • Antibody responses
  • RANDOMIZED CONTROLLED-TRIAL
  • HEMODIALYSIS-PATIENTS
  • RHEUMATIC-DISEASES
  • SUPERIOR IMMUNOGENICITY
  • IMMUNE-RESPONSES
  • ELDERLY-PEOPLE
  • IMMUNIZATION
  • EFFICACY
  • VIRUS
  • SAFETY

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