Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial

Sulin Cheng, Jun Ge, Can Zhao, Shenglong Le, Yifan Yang, Dandan Ke, Na Wu, Xiao Tan, Xiaobo Zhang, Xiaming Du, Jianqin Sun, Renwei Wang, Yongyong Shi, Ronald J. H. Borra, Riitta Parkkola, Petri Wiklund, Dajiang Lu

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Abstract

The study aimed to assess whether aerobic exercise (AEx) training and a fibre-enriched diet can reduce hepatic fat content (HFC) and increase glycaemic control in pre-diabetic patients with non-alcoholic fatty liver disease (NAFLD). Six-hundred-and-three patients from seven clinics in Yangpu district, Shanghai, China were recruited. Of them 115 individuals aged 50-65-year fulfilled the inclusion criteria (NAFLD with impaired fasting glucose or impaired glucose tolerance) and were randomly assigned into exercise (AEx n = 29), diet (Diet n = 28), exercise plus diet (AED n = 29), or no-intervention (NI n = 29) groups. Progressive supervised AEx training (60-75% VO2max intensity) was given 2-3 times/week in 30-60 min/sessions, and the diet intervention was provided as lunch with 38% carbohydrate and diet fibre of 12 g/day for 8.6-month. HFC was assessed by 1H MRS. We found that HFC was significantly reduced in the AEx (-24.4%), diet (-23.2%), and AED (-47.9%) groups by contrast to the 20.9% increase in the NI group (p = 0.001 for all) after intervention. However, only AED group significantly decreased HbA1c (-4.4%, p = 0.01) compared with the NI group (-0.6%). Aerobic exercise training combined with fibre-enriched diet can reduce HFC more effectively than either exercise or increased fibre-intake alone in pre-diabetic patients with NAFLD.

Original languageEnglish
Article number15952
Number of pages11
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 21-Nov-2017

Keywords

  • TYPE-2 DIABETES-MELLITUS
  • IMPAIRED GLUCOSE-TOLERANCE
  • LIFE-STYLE INTERVENTIONS
  • HEPATIC STEATOSIS
  • INSULIN SENSITIVITY
  • NORDIC WALKING
  • WEIGHT-LOSS
  • IN-VIVO
  • SPECTROSCOPY
  • METAANALYSIS

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