Effect of Caloric Restriction on Myocardial Fatty Acid Uptake, Left Ventricular Mass, and Cardiac Work in Obese Adults

Antti P. M. Viljanen; Anna Karmi; Ronald Borra; Jussi P. Parkka; Virva Lepomaki; Riitta Parkkola; Riikka Lautamaki; Mikko Jarvisalo; Markku Taittonen; Tapani Ronnemaa; Patricia Iozzo; Juhani Knuuti; Pirjo Nuutila; Olli T. Raitakari

doi:10.1016/j.amjcard.2009.02.025

Effect of Caloric Restriction on Myocardial Fatty Acid Uptake, Left Ventricular Mass, and Cardiac Work in Obese Adults

Antti P. M. Viljanen^*, Anna Karmi, Ronald Borra, Jussi P. Parkka, Virva Lepomaki, Riitta Parkkola, Riikka Lautamaki, Mikko Jarvisalo, Markku Taittonen, Tapani Ronnemaa, Patricia Iozzo, Juhani Knuuti, Pirjo Nuutila, Olli T. Raitakari

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

66 Citations (Scopus)

Abstract

Obesity is associated with increased fatty acid uptake in the myocardium, and this may have deleterious effects on cardiac function. The aim of this study was to evaluate how weight loss influences myocardial metabolism and cardiac work in obese adults. Thirty-four obese (mean body mass index 33.7 +/- 0.7 kg/m(2)) but otherwise healthy subjects consumed a very low calorie diet for 6 weeks. Cardiac substrate metabolism and work were measured before and after the diet. Myocardial fatty acid uptake was measured in 18 subjects using fluorine-18-fluoro-6-thia-heptadecanoic acid and positron emission tomography, and myocardial glucose uptake was measured in 16 subjects using fluorine-18-2-fluoro-2-deoxyglucose. Myocardial structure and cardiac function were measured using magnetic resonance imaging. Consumption of the very low calorie diet decreased weight (-11.2 +/- 0.6 kg, p

Original language	English
Pages (from-to)	1721-1726
Number of pages	6
Journal	American Journal of Cardiology
Volume	103
Issue number	12
DOIs	https://doi.org/10.1016/j.amjcard.2009.02.025
Publication status	Published - 15-Jun-2009

Keywords

SKELETAL-MUSCLE
GLUCOSE-UPTAKE
IN-VIVO
TRIGLYCERIDE CONTENT
INSULIN-RESISTANCE
HEART
SPECTROSCOPY
DYSFUNCTION
METABOLISM
EFFICIENCY

Access to Document

10.1016/j.amjcard.2009.02.025

Handle.net

Persistent link

Embargoed Document

Effect of Caloric Restriction on Myocardial Fatty Acid Uptake, Left Ventricular Mass, and Cardiac Work in Obese Adults
Final publisher's version, 353 KB

Cite this

Viljanen, A. P. M., Karmi, A., Borra, R., Parkka, J. P., Lepomaki, V., Parkkola, R., Lautamaki, R., Jarvisalo, M., Taittonen, M., Ronnemaa, T., Iozzo, P., Knuuti, J., Nuutila, P., & Raitakari, O. T. (2009). Effect of Caloric Restriction on Myocardial Fatty Acid Uptake, Left Ventricular Mass, and Cardiac Work in Obese Adults. American Journal of Cardiology, 103(12), 1721-1726. https://doi.org/10.1016/j.amjcard.2009.02.025

@article{202855670bd34bc89d9efd31b4030a3e,

title = "Effect of Caloric Restriction on Myocardial Fatty Acid Uptake, Left Ventricular Mass, and Cardiac Work in Obese Adults",

abstract = "Obesity is associated with increased fatty acid uptake in the myocardium, and this may have deleterious effects on cardiac function. The aim of this study was to evaluate how weight loss influences myocardial metabolism and cardiac work in obese adults. Thirty-four obese (mean body mass index 33.7 +/- 0.7 kg/m(2)) but otherwise healthy subjects consumed a very low calorie diet for 6 weeks. Cardiac substrate metabolism and work were measured before and after the diet. Myocardial fatty acid uptake was measured in 18 subjects using fluorine-18-fluoro-6-thia-heptadecanoic acid and positron emission tomography, and myocardial glucose uptake was measured in 16 subjects using fluorine-18-2-fluoro-2-deoxyglucose. Myocardial structure and cardiac function were measured using magnetic resonance imaging. Consumption of the very low calorie diet decreased weight (-11.2 +/- 0.6 kg, p",

keywords = "SKELETAL-MUSCLE, GLUCOSE-UPTAKE, IN-VIVO, TRIGLYCERIDE CONTENT, INSULIN-RESISTANCE, HEART, SPECTROSCOPY, DYSFUNCTION, METABOLISM, EFFICIENCY",

author = "Viljanen, {Antti P. M.} and Anna Karmi and Ronald Borra and Parkka, {Jussi P.} and Virva Lepomaki and Riitta Parkkola and Riikka Lautamaki and Mikko Jarvisalo and Markku Taittonen and Tapani Ronnemaa and Patricia Iozzo and Juhani Knuuti and Pirjo Nuutila and Raitakari, {Olli T.}",

year = "2009",

month = jun,

day = "15",

doi = "10.1016/j.amjcard.2009.02.025",

language = "English",

volume = "103",

pages = "1721--1726",

journal = "American Journal of Cardiology",

issn = "0002-9149",

publisher = "EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC",

number = "12",

}

Viljanen, APM, Karmi, A, Borra, R, Parkka, JP, Lepomaki, V, Parkkola, R, Lautamaki, R, Jarvisalo, M, Taittonen, M, Ronnemaa, T, Iozzo, P, Knuuti, J, Nuutila, P & Raitakari, OT 2009, 'Effect of Caloric Restriction on Myocardial Fatty Acid Uptake, Left Ventricular Mass, and Cardiac Work in Obese Adults', American Journal of Cardiology, vol. 103, no. 12, pp. 1721-1726. https://doi.org/10.1016/j.amjcard.2009.02.025

TY - JOUR

T1 - Effect of Caloric Restriction on Myocardial Fatty Acid Uptake, Left Ventricular Mass, and Cardiac Work in Obese Adults

AU - Viljanen, Antti P. M.

AU - Karmi, Anna

AU - Borra, Ronald

AU - Parkka, Jussi P.

AU - Lepomaki, Virva

AU - Parkkola, Riitta

AU - Lautamaki, Riikka

AU - Jarvisalo, Mikko

AU - Taittonen, Markku

AU - Ronnemaa, Tapani

AU - Iozzo, Patricia

AU - Knuuti, Juhani

AU - Nuutila, Pirjo

AU - Raitakari, Olli T.

PY - 2009/6/15

Y1 - 2009/6/15

N2 - Obesity is associated with increased fatty acid uptake in the myocardium, and this may have deleterious effects on cardiac function. The aim of this study was to evaluate how weight loss influences myocardial metabolism and cardiac work in obese adults. Thirty-four obese (mean body mass index 33.7 +/- 0.7 kg/m(2)) but otherwise healthy subjects consumed a very low calorie diet for 6 weeks. Cardiac substrate metabolism and work were measured before and after the diet. Myocardial fatty acid uptake was measured in 18 subjects using fluorine-18-fluoro-6-thia-heptadecanoic acid and positron emission tomography, and myocardial glucose uptake was measured in 16 subjects using fluorine-18-2-fluoro-2-deoxyglucose. Myocardial structure and cardiac function were measured using magnetic resonance imaging. Consumption of the very low calorie diet decreased weight (-11.2 +/- 0.6 kg, p

AB - Obesity is associated with increased fatty acid uptake in the myocardium, and this may have deleterious effects on cardiac function. The aim of this study was to evaluate how weight loss influences myocardial metabolism and cardiac work in obese adults. Thirty-four obese (mean body mass index 33.7 +/- 0.7 kg/m(2)) but otherwise healthy subjects consumed a very low calorie diet for 6 weeks. Cardiac substrate metabolism and work were measured before and after the diet. Myocardial fatty acid uptake was measured in 18 subjects using fluorine-18-fluoro-6-thia-heptadecanoic acid and positron emission tomography, and myocardial glucose uptake was measured in 16 subjects using fluorine-18-2-fluoro-2-deoxyglucose. Myocardial structure and cardiac function were measured using magnetic resonance imaging. Consumption of the very low calorie diet decreased weight (-11.2 +/- 0.6 kg, p

KW - SKELETAL-MUSCLE

KW - GLUCOSE-UPTAKE

KW - IN-VIVO

KW - TRIGLYCERIDE CONTENT

KW - INSULIN-RESISTANCE

KW - HEART

KW - SPECTROSCOPY

KW - DYSFUNCTION

KW - METABOLISM

KW - EFFICIENCY

U2 - 10.1016/j.amjcard.2009.02.025

DO - 10.1016/j.amjcard.2009.02.025

M3 - Article

SN - 0002-9149

VL - 103

SP - 1721

EP - 1726

JO - American Journal of Cardiology

JF - American Journal of Cardiology

IS - 12

ER -

Effect of Caloric Restriction on Myocardial Fatty Acid Uptake, Left Ventricular Mass, and Cardiac Work in Obese Adults

Abstract

Keywords

Access to Document

Handle.net

Embargoed Document

Fingerprint

Cite this