Effect of different agonistic experiences on behavioural seizures in fully amygdala kindled rats

Hans J.A. Beldhuis*, Jaap M. Koolhaas, Bela Bohus

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    6 Citations (Scopus)
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    Abstract

    Fully amygdala kindled rats were exposed to two different inter-male agonistic experiences in order to study the interaction between epilepsy and acute social stress. Victory experience did not influence the severity of seizure behaviour, whereas a single acute defeat modified both ictal and postictal seizure manifestations. Defeat resulted in less severe and shorter lasting motor seizures, and the accompanied postictal inhibition or behavioural depression was of shorter duration in comparison with pre-stress values. The ability of acute defeat to trigger anticonvulsant activity as implied by the weakened convulsive response is discussed.

    Original languageEnglish
    Pages (from-to)1-4
    Number of pages4
    JournalNeuroscience Letters
    Volume141
    Issue number1
    DOIs
    Publication statusPublished - 6-Jul-1992

    Keywords

    • EPILEPSY
    • AMYGDALA KINDLING
    • MOTOR SEIZURE
    • BEHAVIORAL DEPRESSION
    • ACUTE SOCIAL STRESS
    • DEFEAT
    • ANTICONVULSANT ACTION
    • STRESS
    • GABA
    • MODULATORS
    • RECEPTORS
    • BRAIN

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