Effect of Systolic Blood Pressure on Left Ventricular Structure and Function A Mendelian Randomization Study

Tom Hendriks; M. Abdullah Said; Lara M. A. Janssen; M. Yldau van der Ende; Dirk J. van Veldhuisen; Niek Verweij; Pim van der Harst

doi:10.1161/HYPERTENSIONAHA.119.12679

Effect of Systolic Blood Pressure on Left Ventricular Structure and Function A Mendelian Randomization Study

Tom Hendriks, M. Abdullah Said, Lara M. A. Janssen, M. Yldau van der Ende, Dirk J. van Veldhuisen, Niek Verweij, Pim van der Harst^*

^*Corresponding author for this work

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

130 Downloads (Pure)

Abstract

We aimed to estimate the effects of a lifelong exposure to high systolic blood pressure (SBP) on left ventricular (LV) structure and function using Mendelian randomization. A total of 5596 participants of the UK Biobank were included for whom cardiovascular magnetic resonance imaging and genetic data were available. Major exclusion criteria included nonwhite ethnicity, major cardiovascular disease, and body mass index >30 or

Original language	English
Pages (from-to)	826-832
Number of pages	7
Journal	Hypertension
Volume	74
Issue number	4
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.119.12679
Publication status	Published - Oct-2019

Keywords

biomarker
blood pressure
body surface area
cardiovascular disease
hypertrophy
GENOME-WIDE ASSOCIATION
GENETIC PREDISPOSITION
EJECTION FRACTION
REFERENCE VALUES
RISK-FACTOR
VARIANTS
MASS
METAANALYSIS
HYPERTROPHY
GEOMETRY

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10.1161/HYPERTENSIONAHA.119.12679Licence: CC BY-NC

Effect of Systolic Blood Pressure on Left Ventricular Structure and FunctionFinal publisher's version, 122 KBLicence: CC BY-NC

Cite this

@article{88e8cbbd0ab9445ead37b9a2af5e9146,

title = "Effect of Systolic Blood Pressure on Left Ventricular Structure and Function A Mendelian Randomization Study",

abstract = "We aimed to estimate the effects of a lifelong exposure to high systolic blood pressure (SBP) on left ventricular (LV) structure and function using Mendelian randomization. A total of 5596 participants of the UK Biobank were included for whom cardiovascular magnetic resonance imaging and genetic data were available. Major exclusion criteria included nonwhite ethnicity, major cardiovascular disease, and body mass index >30 or",

keywords = "biomarker, blood pressure, body surface area, cardiovascular disease, hypertrophy, GENOME-WIDE ASSOCIATION, GENETIC PREDISPOSITION, EJECTION FRACTION, REFERENCE VALUES, RISK-FACTOR, VARIANTS, MASS, METAANALYSIS, HYPERTROPHY, GEOMETRY",

author = "Tom Hendriks and Said, {M. Abdullah} and Janssen, {Lara M. A.} and {van der Ende}, {M. Yldau} and {van Veldhuisen}, {Dirk J.} and Niek Verweij and {van der Harst}, Pim",

year = "2019",

month = oct,

doi = "10.1161/HYPERTENSIONAHA.119.12679",

language = "English",

volume = "74",

pages = "826--832",

journal = "Hypertension",

issn = "0194-911X",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "4",

}

Effect of Systolic Blood Pressure on Left Ventricular Structure and Function A Mendelian Randomization Study. / Hendriks, Tom ; Said, M. Abdullah; Janssen, Lara M. A.; van der Ende, M. Yldau; van Veldhuisen, Dirk J.; Verweij, Niek ; van der Harst, Pim.

In: Hypertension, Vol. 74, No. 4, 10.2019, p. 826-832.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Said, M. Abdullah

AU - Janssen, Lara M. A.

AU - van der Ende, M. Yldau

AU - van Veldhuisen, Dirk J.

AU - Verweij, Niek

AU - van der Harst, Pim

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KW - blood pressure

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KW - cardiovascular disease

KW - hypertrophy

KW - GENOME-WIDE ASSOCIATION

KW - GENETIC PREDISPOSITION

KW - EJECTION FRACTION

KW - REFERENCE VALUES

KW - RISK-FACTOR

KW - VARIANTS

KW - MASS

KW - METAANALYSIS

KW - HYPERTROPHY

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