Abstract
We aimed to estimate the effects of a lifelong exposure to high systolic blood pressure (SBP) on left ventricular (LV) structure and function using Mendelian randomization. A total of 5596 participants of the UK Biobank were included for whom cardiovascular magnetic resonance imaging and genetic data were available. Major exclusion criteria included nonwhite ethnicity, major cardiovascular disease, and body mass index >30 or
Original language | English |
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Pages (from-to) | 826-832 |
Number of pages | 7 |
Journal | Hypertension |
Volume | 74 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct-2019 |
Keywords
- biomarker
- blood pressure
- body surface area
- cardiovascular disease
- hypertrophy
- GENOME-WIDE ASSOCIATION
- GENETIC PREDISPOSITION
- EJECTION FRACTION
- REFERENCE VALUES
- RISK-FACTOR
- VARIANTS
- MASS
- METAANALYSIS
- HYPERTROPHY
- GEOMETRY