Effect on hepatic ornithine decarboxylase of some food additives and synthetic elastomers

R Kunnen, B Uijtewaal, R van Wijk, A Bisschop, Louis Jacobus Mgn Van De Zande

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)


he food additives butylated hydroxytoluene, butylated hydroxyanisole and sodium cyclamate and the precursors for packaging materials acrylamide, acrylic acid, acrylonitrile and vinylpyrrolidone were investigated for their ability to induce hepatic ornithine decarboxylase (ODC) in vivo in order to obtain indications about their possible tumour‐promoting activities. It was shown that butylated hydroxyanisole, acrylonitrile, vinylpyrrolidone and acrylamide have the capacity to increase rat liver ODC activity, while butylated hydroxytoluene, acrylic acid and sodium cyclamate did not affect ODC activity.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalFood Additives and Contaminants
Issue number1
Publication statusPublished - 1986
Externally publishedYes

Cite this