Effectiveness of brentuximab vedotin monotherapy in relapsed or refractory Hodgkin lymphoma: a systematic review and meta-analysis

Wouter J. Plattel, Aurore Bergamasco, Fabrizio Trinchese, Francois Gavini, Nawal Bent-Ennakhil, Athanasios Zomas, Genaro Castillon, Teigna Arredondo-Bisono, Tiffany Cristarella, Yola Moride, Bastian von Tresckow*

*Corresponding author for this work

    Research output: Contribution to journalReview articleAcademicpeer-review

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    Abstract

    This systematic review and meta-analysis aimed to determine the effectiveness of brentuximab vedotin (BV) in relapsed/refractory classical Hodgkin lymphoma (R/R cHL) in the clinical practice setting using most recent results. A total of 32 observational studies reporting on treatment patterns, overall response rate (ORR), complete response (CR) rate, progression-free survival (PFS), overall survival (OS), and adverse events were found. After four cycles, a random-effect model yielded pooled ORR and CR rates of 62.6% (95% confidence interval (CI): 56.0-68.9; I-2 = 9.7%) and 32.9% (95% CI, 20.8-46.3, I-2 = 64.8%), respectively. Regarding survival, 1-year, 2-year, and 5-year PFS ranged from 52.1% to 63.2%, 45.2% to 56.2%, and 31.9% to 33.0%, respectively. OS rates were 68.2-82.7%, 58.0-81.9%, and 58.0-62.0%, respectively. Most common adverse events were hematological toxicities (neutropenia: 13.3-23%, anemia: 8.8-39.0%, and thrombocytopenia: 4-4.6%), and grade >= 3 peripheral neuropathy (3.3-7.3%). This study supports the effectiveness and safety of BV in R/R cHL patients in the real-world setting.

    Original languageEnglish
    Pages (from-to)3320-3332
    Number of pages13
    JournalLeukemia & lymphoma
    Volume62
    Issue number14
    DOIs
    Publication statusPublished - 6-Dec-2021

    Keywords

    • Brentuximab vedotin
    • Hodgkin lymphoma
    • effectiveness
    • systematic review
    • meta-analysis
    • STEM-CELL TRANSPLANTATION
    • NAMED PATIENT PROGRAM
    • SINGLE-CENTER
    • ALLOGENEIC TRANSPLANTATION
    • SALVAGE THERAPY
    • PHASE-II
    • EXPERIENCE
    • SURVIVAL
    • OUTCOMES
    • BRIDGE

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