Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia

Jan Albert Kuivenhoven, Greetje J. de Grooth, Hitoshi Kawamura, Anke H. Klerkx, Francois Wilhelm, Mieke D. Trip, John J.P. Kastelein

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Abstract

The inhibition of cholesteryl ester transfer protein (CETP) has recently been shown to effectively increase high-density lipoprotein (HDL) cholesterol. This study examined the use of the CETP inhibitor JTT-705 combined with pravastatin. In a randomized, double-blind, placebo-controlled trial, 155 patients with type II dyslipidemia using pravastatin 40 mg were treated with placebo or JTT-705 300 or 600 mg. Four weeks of treatment with JTT-705 600 mg led to a 30% decrease in CETP activity (p <0.001), a 28% increase in HDL cholesterol (p <0.001), and a 5% decrease in low-density lipoprotein cholesterol (p <0.03). Combination therapy using JTT-705 and pravastatin effectively increases HDL cholesterol levels and is safe and well tolerated up to 4 weeks of administration.

Original languageEnglish
Pages (from-to)1085-1088
Number of pages4
JournalAmerican Journal of Cardiology
Volume95
Issue number9
DOIs
Publication statusPublished - 1-May-2005
Externally publishedYes

Keywords

  • Carrier Proteins
  • Cholesterol Ester Transfer Proteins
  • Cholesterol, HDL
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Glycoproteins
  • Humans
  • Hyperlipidemias
  • Hypolipidemic Agents
  • Male
  • Middle Aged
  • Placebos
  • Pravastatin
  • Sulfhydryl Compounds
  • Treatment Outcome

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