Effectiveness of late-life depression interventions on functional limitations: A systematic review

Sanne Wassink-Vossen*, Richard C Oude Voshaar, Paul Naarding, Rose M Collard

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Depression is one of the most prevalent mental disorders in older adults and leads to considerable decreases in health, well-being, and impaired functioning. Intervention studies have focused on the effects on symptomatic recovery, and most do not include functional recovery as an outcome. Reduction of functional limitations as a treatment goal in old-age psychiatry aligns with the values of older persons. The objective of this review was therefore to evaluate the effectiveness of late-life depression interventions on functional limitations. This systematic review identified 15 randomized controlled trials in which the effectiveness of different interventions on functional limitations was evaluated in patients with late-life depression. The interventions were categorized into four categories: psychological interventions, drug treatment, physical exercise, and collaborative care. Multicomponent and collaborative-care interventions appear to be the most promising for improvement of functional limitations, particularly in primary care and community-dwelling populations of older persons with symptoms of depression. There is, however, a lack of evidence regarding studies in specialized mental health care.

Original languageEnglish
Pages (from-to)823-842
Number of pages20
JournalInternational Journal of Mental Health Nursing
Issue number4
Early online date9-Feb-2022
Publication statusPublished - Aug-2022

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