Effects of Caffeine on Myocardial Blood Flow: A Systematic Review

Randy van Dijk, Daan Ties, Dirkjan Kuijpers, Pim van der Harst, Matthijs Oudkerk*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)
234 Downloads (Pure)

Abstract

Background. Caffeine is one of the most widely consumed stimulants worldwide. It is a well-recognized antagonist of adenosine and a potential cause of false-negative functional measurements during vasodilator myocardial perfusion. The aim of this systematic review is to summarize the evidence regarding the effects of caffeine intake on functional measurements of myocardial perfusion in patients with suspected coronary artery disease. Pubmed, Web of Science, and Embase were searched using a predefined electronic search strategy. Participantshealthy subjects or patients with known or suspected CAD. Comparisonsrecent caffeine intake versus no caffeine intake. Outcomesmeasurements of functional myocardial perfusion. Study designobservational. Fourteen studies were deemed eligible for this systematic review. There was a wide range of variability in study design with varying imaging modalities, vasodilator agents, serum concentrations of caffeine, and primary outcome measurements. The available data indicate a significant influence of recent caffeine intake on cardiac perfusion measurements during adenosine and dipyridamole induced hyperemia. These effects have the potential to affect the clinical decision making by re-classification to different risk-categories.

Original languageEnglish
Article number1083
Number of pages14
JournalNutrients
Volume10
Issue number8
DOIs
Publication statusPublished - Aug-2018

Keywords

  • caffeine
  • myocardial perfusion
  • coronary artery disease
  • adenosine
  • regadenoson
  • dipyridamole
  • CORONARY-ARTERY-DISEASE
  • EMISSION COMPUTED-TOMOGRAPHY
  • MAGNETIC-RESONANCE PERFUSION
  • ADENOSINE-INDUCED HYPEREMIA
  • PHARMACOLOGICAL STRESS
  • A(2A) AGONIST
  • REGADENOSON
  • RESERVE
  • VASODILATION
  • TRIPHOSPHATE

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