Effects of canagliflozin on cardiovascular, renal, and safety outcomes in participants with type 2 diabetes and chronic kidney disease according to history of heart failure: Results from the CREDENCE trial

Ashish Sarraju; JingWei Li; Christopher P. Cannon; Tara Chang; Rajiv Agarwal; George Bakris; David M. Charytan; Dick de Zeeuw; Tom Greene; Hiddo J. L. Heerspink; Adeera Levin; Bruce Neal; Carol Pollock; David C. Wheeler; Yshai Yavin; Hong Zhang; Bernard Zinman; Vlado Perkovic; Meg Jardine; Kenneth W. Mahaffey

doi:10.1016/j.ahj.2020.12.008

Effects of canagliflozin on cardiovascular, renal, and safety outcomes in participants with type 2 diabetes and chronic kidney disease according to history of heart failure: Results from the CREDENCE trial

Ashish Sarraju, JingWei Li, Christopher P. Cannon, Tara Chang, Rajiv Agarwal, George Bakris, David M. Charytan, Dick de Zeeuw, Tom Greene, Hiddo J. L. Heerspink, Adeera Levin, Bruce Neal, Carol Pollock, David C. Wheeler, Yshai Yavin, Hong Zhang, Bernard Zinman, Vlado Perkovic, Meg Jardine, Kenneth W. Mahaffey^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We aimed to assess the efficacy and safety of canagliflozin in patients with type 2 diabetes and nephropathy according to prior history of heart failure in the Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation (CREDENCE) trial. We found that participants with a prior history of heart failure at baseline (15%) were more likely to be older, female, white, have a history of atherosclerotic cardiovascular disease, and use diuretics and beta blockers (all P <.001), and that, compared with placebo, canagliflozin safely reduced renal and cardiovascular events with consistent effects in patients with and without a prior history of heart failure (all efficacy P interaction >.150). These results support the efficacy and safety of canagliflozin in patients with type 2 diabetes and nephropathy regardless of prior history of heart failure.

Original language	English
Pages (from-to)	141-148
Number of pages	8
Journal	American Heart Journal
Volume	233
DOIs	https://doi.org/10.1016/j.ahj.2020.12.008
Publication status	Published - Mar-2021

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Effects of canagliflozin on cardiovascular, renal, and safety outcomes in participants with type 2 diabetes and chronic kidney disease according to history of heart failure_ Results from the CREDENCE trialFinal publisher's version, 3.31 MBLicence: Taverne

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Sarraju, A., Li, J., Cannon, C. P., Chang, T., Agarwal, R., Bakris, G., Charytan, D. M., de Zeeuw, D., Greene, T., Heerspink, H. J. L., Levin, A., Neal, B., Pollock, C., Wheeler, D. C., Yavin, Y., Zhang, H., Zinman, B., Perkovic, V., Jardine, M., & Mahaffey, K. W. (2021). Effects of canagliflozin on cardiovascular, renal, and safety outcomes in participants with type 2 diabetes and chronic kidney disease according to history of heart failure: Results from the CREDENCE trial. American Heart Journal, 233, 141-148. https://doi.org/10.1016/j.ahj.2020.12.008

@article{70b358bef6cf4baf9bc55e16dfffffb7,

title = "Effects of canagliflozin on cardiovascular, renal, and safety outcomes in participants with type 2 diabetes and chronic kidney disease according to history of heart failure: Results from the CREDENCE trial",

abstract = "We aimed to assess the efficacy and safety of canagliflozin in patients with type 2 diabetes and nephropathy according to prior history of heart failure in the Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation (CREDENCE) trial. We found that participants with a prior history of heart failure at baseline (15%) were more likely to be older, female, white, have a history of atherosclerotic cardiovascular disease, and use diuretics and beta blockers (all P <.001), and that, compared with placebo, canagliflozin safely reduced renal and cardiovascular events with consistent effects in patients with and without a prior history of heart failure (all efficacy P interaction >.150). These results support the efficacy and safety of canagliflozin in patients with type 2 diabetes and nephropathy regardless of prior history of heart failure.",

author = "Ashish Sarraju and JingWei Li and Cannon, {Christopher P.} and Tara Chang and Rajiv Agarwal and George Bakris and Charytan, {David M.} and {de Zeeuw}, Dick and Tom Greene and Heerspink, {Hiddo J. L.} and Adeera Levin and Bruce Neal and Carol Pollock and Wheeler, {David C.} and Yshai Yavin and Hong Zhang and Bernard Zinman and Vlado Perkovic and Meg Jardine and Mahaffey, {Kenneth W.}",

year = "2021",

month = mar,

doi = "10.1016/j.ahj.2020.12.008",

language = "English",

volume = "233",

pages = "141--148",

journal = "American Heart Journal",

issn = "0002-8703",

publisher = "MOSBY-ELSEVIER",

}

Sarraju, A, Li, J, Cannon, CP, Chang, T, Agarwal, R, Bakris, G, Charytan, DM, de Zeeuw, D, Greene, T, Heerspink, HJL, Levin, A, Neal, B, Pollock, C, Wheeler, DC, Yavin, Y, Zhang, H, Zinman, B, Perkovic, V, Jardine, M & Mahaffey, KW 2021, 'Effects of canagliflozin on cardiovascular, renal, and safety outcomes in participants with type 2 diabetes and chronic kidney disease according to history of heart failure: Results from the CREDENCE trial', American Heart Journal, vol. 233, pp. 141-148. https://doi.org/10.1016/j.ahj.2020.12.008

Effects of canagliflozin on cardiovascular, renal, and safety outcomes in participants with type 2 diabetes and chronic kidney disease according to history of heart failure: Results from the CREDENCE trial. / Sarraju, Ashish; Li, JingWei; Cannon, Christopher P. et al.
In: American Heart Journal, Vol. 233, 03.2021, p. 141-148.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Cannon, Christopher P.

AU - Chang, Tara

AU - Agarwal, Rajiv

AU - Bakris, George

AU - Charytan, David M.

AU - de Zeeuw, Dick

AU - Greene, Tom

AU - Heerspink, Hiddo J. L.

AU - Levin, Adeera

AU - Neal, Bruce

AU - Pollock, Carol

AU - Wheeler, David C.

AU - Yavin, Yshai

AU - Zhang, Hong

AU - Zinman, Bernard

AU - Perkovic, Vlado

AU - Jardine, Meg

AU - Mahaffey, Kenneth W.

PY - 2021/3

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AB - We aimed to assess the efficacy and safety of canagliflozin in patients with type 2 diabetes and nephropathy according to prior history of heart failure in the Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation (CREDENCE) trial. We found that participants with a prior history of heart failure at baseline (15%) were more likely to be older, female, white, have a history of atherosclerotic cardiovascular disease, and use diuretics and beta blockers (all P <.001), and that, compared with placebo, canagliflozin safely reduced renal and cardiovascular events with consistent effects in patients with and without a prior history of heart failure (all efficacy P interaction >.150). These results support the efficacy and safety of canagliflozin in patients with type 2 diabetes and nephropathy regardless of prior history of heart failure.

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JO - American Heart Journal

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