Effects of fasting on plasma catecholamine, corticosterone and glucose concentrations under basal and stress conditions in individual rats

S.F. de Boer, S.J. Koopmans, J L Slangen, J Van der Gugten

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    60 Citations (Scopus)

    Abstract

    Plasma noradrenaline (NA), adrenaline (A), corticosterone (CS) and glucose concentrations were determined in blood sampled via a cardiac catheter from freely moving male rats under ad lib fed and 24 hr food deprived conditions using a repeated measures within-subject design. Resting plasma NA and glucose levels were lower in the fasted condition as compared to the fed situation. One day of refeeding reinstated the decreased NA and glucose values to prefasting level. Exposing 24 hr food deprived animals to the psychological stress of a novel environment resulted in larger NA and glucose increases, an unchanged A release and a lower CS rise in comparison with the responses during the free feeding state. The results show the usefulness of a within-subject design to detect subtle changes in plasma NA contents. Additionally, the data support the concept of selective control of the sympathetic nervous system and adrenal medullae. It is argued that hypothalamic noradrenergic mechanisms may be linked to the fasting-induced effects on the sympatho-adrenal system.

    Original languageEnglish
    Pages (from-to)989-994
    Number of pages6
    JournalPhysiology & Behavior
    Volume45
    Issue number5
    DOIs
    Publication statusPublished - May-1989

    Keywords

    • Animals
    • Blood Glucose
    • Body Weight
    • Corticosterone
    • Epinephrine
    • Food Deprivation
    • Male
    • Norepinephrine
    • Rats
    • Rats, Inbred Strains
    • Stress, Psychological
    • Time Factors

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