TY - JOUR
T1 - Effects of gamma-aminobutyric acid on working memory and attention
T2 - A randomized, double-blinded, placebo-controlled, crossover trial
AU - Altınok, Ahmet
AU - Karabay, Aytaç
AU - Jong, Joost de
AU - Balta, Gülşen
AU - Akyürek, Elkan G.
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023/6
Y1 - 2023/6
N2 - Background: γ-Aminobutyric acid (GABA) is a primary inhibitory neurotransmitter that plays a significant role in the central nervous system. Studies on both animals and humans show that GABA has the pharmacological potential for reducing the impact of cognitive disorders, as well as enhancing cognitive functions and mood. However, its specific effects on human attention and working memory have not yet been extensively studied. Aims: In this randomized, double-blind, placebo-controlled, and crossover trial, we aimed to test whether the administration of 800 mg GABA, dissolved in a drink, acutely affected visual working memory (VWM) maintenance, as well as temporal and spatial attention in healthy adults. Methods: The participants were 32 young adults (16 females and 16 males). Working memory recall precision, spatial attention and temporal attention were measured by a delayed match-to-sample task, a visual search (VS) task and a speeded rapid serial visual presentation task, respectively. Participants completed two experimental sessions (GABA and Placebo) in randomized and counterbalanced order. In each session, 45 min after administration of the drink, they completed all three aforementioned cognitive tasks. Results: Linear mixed model analysis results showed that GABA increased VS time, compared to the placebo, but did not affect VS accuracy, temporal attention, nor VWM precision. Conclusions: The results suggest that GABA increases VS time but does not affect temporal attention and memory, and that previously reported effects on cognition might rely on other functions.
AB - Background: γ-Aminobutyric acid (GABA) is a primary inhibitory neurotransmitter that plays a significant role in the central nervous system. Studies on both animals and humans show that GABA has the pharmacological potential for reducing the impact of cognitive disorders, as well as enhancing cognitive functions and mood. However, its specific effects on human attention and working memory have not yet been extensively studied. Aims: In this randomized, double-blind, placebo-controlled, and crossover trial, we aimed to test whether the administration of 800 mg GABA, dissolved in a drink, acutely affected visual working memory (VWM) maintenance, as well as temporal and spatial attention in healthy adults. Methods: The participants were 32 young adults (16 females and 16 males). Working memory recall precision, spatial attention and temporal attention were measured by a delayed match-to-sample task, a visual search (VS) task and a speeded rapid serial visual presentation task, respectively. Participants completed two experimental sessions (GABA and Placebo) in randomized and counterbalanced order. In each session, 45 min after administration of the drink, they completed all three aforementioned cognitive tasks. Results: Linear mixed model analysis results showed that GABA increased VS time, compared to the placebo, but did not affect VS accuracy, temporal attention, nor VWM precision. Conclusions: The results suggest that GABA increases VS time but does not affect temporal attention and memory, and that previously reported effects on cognition might rely on other functions.
KW - crossover trial
KW - Gamma-aminobutyric acid
KW - spatial attention
KW - temporal attention
KW - working memory
UR - http://www.scopus.com/inward/record.url?scp=85152291996&partnerID=8YFLogxK
U2 - 10.1177/02698811231161579
DO - 10.1177/02698811231161579
M3 - Article
C2 - 36988214
AN - SCOPUS:85152291996
SN - 0269-8811
VL - 37
SP - 554
EP - 565
JO - Journal of Psychopharmacology
JF - Journal of Psychopharmacology
IS - 6
ER -