Abstract
The influence of halopemide, a new psychotropic agent, and some putative metabolites on the uptake of14C-5-HT into blood platelets of rat and man were studied and compared to the effects of imipramine, sulpiride and clozapine. Halopemide, its putative metabolites R 38570 and R 29676 and sulpiride inhibited the uptake in a dose-dependent manner, but the compounds were less active than imipramine. Clozapine and p-fluorohippuric acid, another putative metabolite of halopemide, were totally devoid of activity.
Original language | English |
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Pages (from-to) | 267-274 |
Number of pages | 8 |
Journal | Archives internationales de pharmacodynamie et de therapie |
Volume | 237 |
Issue number | 2 |
Publication status | Published - 22-Apr-1979 |
Keywords
- 1 [1 (2 aminoethyl) 4 piperidyl] 5 chloro 1,3 dihydro 2h benzimidazol 2 one
- 4 fluorohippuric acid
- 5 chloro 1 (4 piperidyl) 1,3 dihydro 2h benzimidazol 2 one
- 5 chloro 1,3 dihydro 1 (4 piperidinyl)benzimidazol 2(2h) one
- clozapine
- drug metabolite
- halopemide
- imipramine
- n,n dimethylformamide
- r38570
- radioisotope
- serotonin
- serotonin c 14
- serotonin creatinine sulfate c 14
- sulpiride
- thrombocyte serotonin
- unclassified drug
- animal experiment
- article
- drug comparison
- drug response
- human
- human cell
- in vitro study
- rat
- thrombocyte