Effects of halopemide, a new psychotropic agent, on the uptake of serotonin by blood platelets

A.J.M. Loonen, W. Soudijn

    Research output: Contribution to journalArticleAcademicpeer-review

    7 Citations (Scopus)

    Abstract

    The influence of halopemide, a new psychotropic agent, and some putative metabolites on the uptake of14C-5-HT into blood platelets of rat and man were studied and compared to the effects of imipramine, sulpiride and clozapine. Halopemide, its putative metabolites R 38570 and R 29676 and sulpiride inhibited the uptake in a dose-dependent manner, but the compounds were less active than imipramine. Clozapine and p-fluorohippuric acid, another putative metabolite of halopemide, were totally devoid of activity.
    Original languageEnglish
    Pages (from-to)267-274
    Number of pages8
    JournalArchives internationales de pharmacodynamie et de therapie
    Volume237
    Issue number2
    Publication statusPublished - 22-Apr-1979

    Keywords

    • 1 [1 (2 aminoethyl) 4 piperidyl] 5 chloro 1,3 dihydro 2h benzimidazol 2 one
    • 4 fluorohippuric acid
    • 5 chloro 1 (4 piperidyl) 1,3 dihydro 2h benzimidazol 2 one
    • 5 chloro 1,3 dihydro 1 (4 piperidinyl)benzimidazol 2(2h) one
    • clozapine
    • drug metabolite
    • halopemide
    • imipramine
    • n,n dimethylformamide
    • r38570
    • radioisotope
    • serotonin
    • serotonin c 14
    • serotonin creatinine sulfate c 14
    • sulpiride
    • thrombocyte serotonin
    • unclassified drug
    • animal experiment
    • article
    • drug comparison
    • drug response
    • human
    • human cell
    • in vitro study
    • rat
    • thrombocyte

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