Effects of halopemide on potassium-induced release of radiolabeled neurotransmitters from rat cerebrocortical slices in vitro

A.J.M. Loonen, W. Soudijn

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3 Citations (Scopus)

Abstract

The effects of halopemide on the release of3H-serotonin,3H-noradrenaline,3H-acetylcholine and3H-GABA from rat frontal cortical slices in vitro were studied and compared to those of its neuroleptic congener R29800, spiperone and haloperidol. Spontaneous3H-serotonin and to a lesser extent3H-noradrenaline outflow were augmented by the agents, while the effects on basal3H-acetylcholine and3H-GABA release were small or absent. Mechanisms explaining these effects are discussed. Depolarization-induced release of serotonin was affected more markedly than the extra overflow of other radiolabeled transmitters, but the statistical significance of the response was limited.
Original languageEnglish
Pages (from-to)43-58
Number of pages16
JournalArchives internationales de pharmacodynamie et de therapie
Volume247
Issue number1
Publication statusPublished - 22-Apr-1980
Externally publishedYes

Keywords

  • 4 aminobutyric acid h 3
  • 5 chloro 1 [1 [3 (4 fluorobenzoyl)propyl] 4 piperidyl] 1,3 dihydro 2h benzimidazol 2 one
  • acetylcholine h 3
  • choline h 3
  • halopemide
  • haloperidol
  • imipramine
  • neurotransmitter
  • noradrenalin h 3
  • radioisotope
  • serotonin h 3
  • spiperone
  • unclassified drug
  • animal experiment
  • article
  • brain slice
  • central nervous system
  • frontal cortex
  • in vitro study
  • rat

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