Abstract
The effects of halopemide on the release of3H-serotonin,3H-noradrenaline,3H-acetylcholine and3H-GABA from rat frontal cortical slices in vitro were studied and compared to those of its neuroleptic congener R29800, spiperone and haloperidol. Spontaneous3H-serotonin and to a lesser extent3H-noradrenaline outflow were augmented by the agents, while the effects on basal3H-acetylcholine and3H-GABA release were small or absent. Mechanisms explaining these effects are discussed. Depolarization-induced release of serotonin was affected more markedly than the extra overflow of other radiolabeled transmitters, but the statistical significance of the response was limited.
| Original language | English |
|---|---|
| Pages (from-to) | 43-58 |
| Number of pages | 16 |
| Journal | Archives internationales de pharmacodynamie et de therapie |
| Volume | 247 |
| Issue number | 1 |
| Publication status | Published - 22-Apr-1980 |
| Externally published | Yes |
Keywords
- 4 aminobutyric acid h 3
- 5 chloro 1 [1 [3 (4 fluorobenzoyl)propyl] 4 piperidyl] 1,3 dihydro 2h benzimidazol 2 one
- acetylcholine h 3
- choline h 3
- halopemide
- haloperidol
- imipramine
- neurotransmitter
- noradrenalin h 3
- radioisotope
- serotonin h 3
- spiperone
- unclassified drug
- animal experiment
- article
- brain slice
- central nervous system
- frontal cortex
- in vitro study
- rat