Abstract
We assessed the effect of insulin and atrial natriuretic peptide (ANP) on renal sodium handling in eight patients with sickle cell disease (SCD), who are characterized by loss of vasa recta and long loops of Henle, and matched control subjects. During insulin infusion (50 mU.kg(-1).h(-1)), fractional sodium excretion decreased by 0.44 +/- 0.72% (P = 0.13) in patients with SCD and by 0.57 +/- 0.34% (P = 0.002) in control;subjects, whereas fractional distal sodium reabsorption increased by 4.1 +/- 1.5% (P <0.001) and 3.0 +/- 1.5% (P
| Original language | English |
|---|---|
| Pages (from-to) | F499-F505 |
| Number of pages | 7 |
| Journal | American journal of physiology-Renal physiology |
| Volume | 278 |
| Issue number | 3 |
| Publication status | Published - Mar-2000 |
Keywords
- loop of Henle
- sickle hemoglobin
- lithium
- medullary blood flow
- GLOMERULAR-FILTRATION RATE
- EXOGENOUS INSULIN
- HEALTHY-VOLUNTEERS
- COLLECTING DUCT
- PRESSURE
- HUMANS
- LOOP
- ANP
- SEGMENTS
- NEPHRON