Abstract
Background: Wound contraction and scar formation in the palatal mucoperiosteum after cleft palate surgery impair maxillary growth. The aim of this study was to determine the effects of IFN-beta on palatal mucoperiosteal wound healing in growing rats.
Methods: Standardized wounds were made in the palatal mucoperiosteum of young rats. Either IFN-beta or vehicle were injected at the wound site between 4 and 29 days after wounding. The results were compared with control wounds. Tissue samples were collected at 8, 15, 30, and 60 days PW for biochemical and microscopic analysis.
Results: IFN-beta stimulated re-epithelialization but did not reduce the number of myofibroblasts or scar tissue formation. Surprisingly, the injection of vehicle alone delayed the healing process.
Conclusion: IFN-beta might be suitable to stimulate re-epithelialization but it does not reduce scar tissue formation in rat palatal wound healing. The injection of agents into palatal wounds might severely impair the healing process.
| Original language | English |
|---|---|
| Pages (from-to) | 518-525 |
| Number of pages | 8 |
| Journal | Journal of oral pathology & medicine |
| Volume | 31 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Oct-2002 |
| Externally published | Yes |
Keywords
- interferon
- palate
- rat
- wound healing
- SMOOTH MUSCLE ACTIN
- DERMAL FIBROBLASTS
- COLLAGEN-SYNTHESIS
- GAMMA-INTERFERON
- MYOFIBROBLASTS
- ALPHA
- TISSUE
- RAT
- PENTOXIFYLLINE
- CONTRACTION