Effects of prednisone and splenectomy in patients with idiopathic thrombocytopenic purpura: only splenectomy induces a complete remission

H Louwes, E Vellenga, EJ Houwerzijl, JTM de Wolf*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

Idiopathic thrombocytopenic purpura (ITP) is a heterogeneous disease, whereby it is unclear if and in which way prednisone and splenectomy affect the platelet kinetics leading to a complete remission. To determine the effects of prednisone and splenectomy on the mean platelet life (MPL) and platelet production, platelet kinetic studies with Indium-111 tropolonate-labeled autologous platelets were performed in patients with ITP (n=41). In 17 patients platelet kinetic studies were performed before and during prednisone treatment, and in 24 patients before and after splenectomy. MPL increased after prednisone therapy only in patients (n=13) with a full recovery (FR, platelets >150x10(9)/l) and partial recovery (PR, 50x10(9)/l

Original languageEnglish
Pages (from-to)728-732
Number of pages5
JournalAnnals of Hematology
Volume80
Issue number12
Publication statusPublished - Dec-2001

Keywords

  • idiopathic thrombocytopenic purpura (ITP)
  • treatment
  • prednisone
  • splenectomy
  • platelet kinetics

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