Efficient C2 functionalisation of 2H-2-imidazolines

Robin S. Bon; Nanda E. Sprenkels; Manoe M. Koningstein; Rob F. Schmitz; Frans J. J. de Kanter; Alexander Doemling; Marinus B. Groen; Romano V. A. Orru

doi:10.1039/b713065a

Efficient C2 functionalisation of 2H-2-imidazolines

Robin S. Bon, Nanda E. Sprenkels, Manoe M. Koningstein, Rob F. Schmitz, Frans J. J. de Kanter, Alexander Doemling, Marinus B. Groen, Romano V. A. Orru^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

Abstract

Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).

Original language	English
Pages (from-to)	130-137
Number of pages	8
Journal	Organic & Biomolecular Chemistry
Volume	6
Issue number	1
DOIs	https://doi.org/10.1039/b713065a
Publication status	Published - 2008
Externally published	Yes

Keywords

2-IMIDAZOLINES
ACID
P53
DERIVATIVES
ANTAGONISTS
MDM2

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title = "Efficient C2 functionalisation of 2H-2-imidazolines",

abstract = "Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).",

keywords = "2-IMIDAZOLINES, ACID, P53, DERIVATIVES, ANTAGONISTS, MDM2",

author = "Bon, {Robin S.} and Sprenkels, {Nanda E.} and Koningstein, {Manoe M.} and Schmitz, {Rob F.} and {de Kanter}, {Frans J. J.} and Alexander Doemling and Groen, {Marinus B.} and Orru, {Romano V. A.}",

year = "2008",

doi = "10.1039/b713065a",

language = "English",

volume = "6",

pages = "130--137",

journal = "Organic & Biomolecular Chemistry",

issn = "1477-0520",

publisher = "ROYAL SOC CHEMISTRY",

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TY - JOUR

T1 - Efficient C2 functionalisation of 2H-2-imidazolines

AU - Bon, Robin S.

AU - Sprenkels, Nanda E.

AU - Koningstein, Manoe M.

AU - Schmitz, Rob F.

AU - de Kanter, Frans J. J.

AU - Doemling, Alexander

AU - Groen, Marinus B.

AU - Orru, Romano V. A.

PY - 2008

Y1 - 2008

N2 - Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).

AB - Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).

KW - 2-IMIDAZOLINES

KW - ACID

KW - P53

KW - DERIVATIVES

KW - ANTAGONISTS

KW - MDM2

U2 - 10.1039/b713065a

DO - 10.1039/b713065a

M3 - Article

SN - 1477-0520

VL - 6

SP - 130

EP - 137

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 1

ER -

Efficient C2 functionalisation of 2H-2-imidazolines

Abstract

Keywords

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