Efficient polarization transfer between spin-1/2 and<sup>14</sup>N nuclei in solid-state MAS NMR spectroscopy

K. Basse, Sheetal Kumar Jain, Oleg N. Bakharev, Niels Christian Nielsen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

Polarization transfer between spin-1/2 nuclei and quadrupolar spin-1 nuclei such as
N in solid-state NMR is severely challenged by the typical presence of large quadrupole coupling interactions. This has effectively prevented the use of the abundant
N spin as a probe to structural information and its use as an element in multi-dimensional solid-state NMR correlation experiments for assignment and structural characterization. In turn, this has been a contributing factor to the extensive use of isotope labeling in biological solid-state NMR, where
N is replaced with
N. The alternative strategy of using the abundant
N spins calls for methods enabling efficient polarization transfer between
N and its binding partners. This work demonstrates that the recently introduced
CP transfer method can be optimized to achieve efficient
H

N polarization transfer under magic angle spinning conditions. The method is demonstrated numerically and experimentally on powder samples of NH4NO3 and l-alanine.
Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalJournal of Magnetic Resonance
Volume244
DOIs
Publication statusPublished - 2014
Externally publishedYes

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