Elevated circulating stromal-derived factor-1 levels in sickle cell disease

P P Landburg, E Nur, N Maria, D P M Brandjes, B J Biemond, J B Schnog, A J Duits, CURAMA study group

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    Abstract

    Inflammation and angiogenesis are of importance in the pathophysiology of sickle cell disease (SCD). Recently, the chemokine stromal-derived factor-1 (SDF-1) has been shown to be a key mediator of angiogenesis and inflammation. In this study we determined serum SDF-1 levels in consecutive adult sickle cell patients during the clinically asymptomatic state as well as during painful crisis. Serum SDF-1 levels were significantly elevated in HbSS/HbSbeta(0)-thalassaemia patients [n = 42; 5,177 pg/ml (2,438-7,246)] compared to HbSC/HbSbeta(+)-thalassaemia patients [n = 16; 2,405 pg/ml (1,365-3,047)] and healthy HbAA controls [n = 45; 2,894 pg/ml (2,577-3,334)] (p = 0.001). No significant increments were observed during painful crisis (n = 40). SDF-1 levels were significantly higher in SCD patients with pulmonary hypertension (PHT) compared to patients without PHT. Elevated circulating SDF-1 levels occur in patients with SCD and may play a role in the pathophysiology of SCD-related PHT.

    Original languageEnglish
    Pages (from-to)64-9
    Number of pages6
    JournalACTA HAEMATOLOGICA
    Volume122
    Issue number1
    DOIs
    Publication statusPublished - 2009

    Keywords

    • Adult
    • Anemia, Sickle Cell
    • Chemokine CXCL12
    • Female
    • Humans
    • Hypertension, Pulmonary
    • Male
    • Middle Aged
    • Pain

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