Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing

Christof Niehrs; Cornelis F. Calkhoven

doi:10.1016/j.tig.2019.11.005

Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing

Christof Niehrs^*, Cornelis F. Calkhoven

^*Corresponding author for this work

Stem Cell Aging Leukemia and Lymphoma (SALL)

Research output: Contribution to journal › Review article › Academic › peer-review

7 Citations (Scopus)

7 Downloads (Pure)

Abstract

Changes in epigenetic DNA methylation are the most promising predictor of biological age and lifespan in humans, but whether methylation changes affect ageing is unresolved. Here, we discuss converging data, which indicate that one mode by which aberrant DNA methylation can affect ageing is via CCAAT/enhancer binding protein beta (C/EBPβ). This basic leucine-zipper (bZIP) transcription factor is controlled by the lifespan regulator mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and plays an important role in energy homeostasis and adipose tissue differentiation. Emerging evidence indicates that access of C/EBPβ proteins to cognate binding sites is regulated by DNA demethylation via ten-eleven translocation (TET) methylcytosine dioxygenases and their adaptor proteins growth arrest and DNA damage-inducible protein 45 alpha (GADD45α) and inhibitor of growth 1 (ING1). We discuss the emerging causal nexus between C/EBPβ, energy metabolism, and DNA demethylation in organismal ageing.

Original language	English
Pages (from-to)	71-80
Number of pages	10
Journal	Trends in Genetics
Volume	36
Issue number	2
Early online date	7-Dec-2019
DOIs	https://doi.org/10.1016/j.tig.2019.11.005
Publication status	Published - Feb-2020

Keywords

BINDING-PROTEIN-BETA
MESSENGER-RNA
ALPHA
AGE
GENE
CELLS
TRANSLATION
TISSUE
GADD45A
ARREST

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10.1016/j.tig.2019.11.005

Emerging Role of C_EBPβ and Epigenetic DNA Methylation in Ageing _ Elsevier Enhanced ReaderFinal publisher's version, 4.68 MBLicence: Taverne

Cite this

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title = "Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing",

abstract = "Changes in epigenetic DNA methylation are the most promising predictor of biological age and lifespan in humans, but whether methylation changes affect ageing is unresolved. Here, we discuss converging data, which indicate that one mode by which aberrant DNA methylation can affect ageing is via CCAAT/enhancer binding protein beta (C/EBPβ). This basic leucine-zipper (bZIP) transcription factor is controlled by the lifespan regulator mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and plays an important role in energy homeostasis and adipose tissue differentiation. Emerging evidence indicates that access of C/EBPβ proteins to cognate binding sites is regulated by DNA demethylation via ten-eleven translocation (TET) methylcytosine dioxygenases and their adaptor proteins growth arrest and DNA damage-inducible protein 45 alpha (GADD45α) and inhibitor of growth 1 (ING1). We discuss the emerging causal nexus between C/EBPβ, energy metabolism, and DNA demethylation in organismal ageing.",

keywords = "BINDING-PROTEIN-BETA, MESSENGER-RNA, ALPHA, AGE, GENE, CELLS, TRANSLATION, TISSUE, GADD45A, ARREST",

author = "Christof Niehrs and Calkhoven, {Cornelis F.}",

year = "2020",

month = feb,

doi = "10.1016/j.tig.2019.11.005",

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TY - JOUR

T1 - Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing

AU - Niehrs, Christof

AU - Calkhoven, Cornelis F.

PY - 2020/2

Y1 - 2020/2

N2 - Changes in epigenetic DNA methylation are the most promising predictor of biological age and lifespan in humans, but whether methylation changes affect ageing is unresolved. Here, we discuss converging data, which indicate that one mode by which aberrant DNA methylation can affect ageing is via CCAAT/enhancer binding protein beta (C/EBPβ). This basic leucine-zipper (bZIP) transcription factor is controlled by the lifespan regulator mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and plays an important role in energy homeostasis and adipose tissue differentiation. Emerging evidence indicates that access of C/EBPβ proteins to cognate binding sites is regulated by DNA demethylation via ten-eleven translocation (TET) methylcytosine dioxygenases and their adaptor proteins growth arrest and DNA damage-inducible protein 45 alpha (GADD45α) and inhibitor of growth 1 (ING1). We discuss the emerging causal nexus between C/EBPβ, energy metabolism, and DNA demethylation in organismal ageing.

AB - Changes in epigenetic DNA methylation are the most promising predictor of biological age and lifespan in humans, but whether methylation changes affect ageing is unresolved. Here, we discuss converging data, which indicate that one mode by which aberrant DNA methylation can affect ageing is via CCAAT/enhancer binding protein beta (C/EBPβ). This basic leucine-zipper (bZIP) transcription factor is controlled by the lifespan regulator mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and plays an important role in energy homeostasis and adipose tissue differentiation. Emerging evidence indicates that access of C/EBPβ proteins to cognate binding sites is regulated by DNA demethylation via ten-eleven translocation (TET) methylcytosine dioxygenases and their adaptor proteins growth arrest and DNA damage-inducible protein 45 alpha (GADD45α) and inhibitor of growth 1 (ING1). We discuss the emerging causal nexus between C/EBPβ, energy metabolism, and DNA demethylation in organismal ageing.

KW - BINDING-PROTEIN-BETA

KW - MESSENGER-RNA

KW - ALPHA

KW - AGE

KW - GENE

KW - CELLS

KW - TRANSLATION

KW - TISSUE

KW - GADD45A

KW - ARREST

U2 - 10.1016/j.tig.2019.11.005

DO - 10.1016/j.tig.2019.11.005

M3 - Review article

C2 - 31822355

VL - 36

SP - 71

EP - 80

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 2

ER -