Enaminen van 3-ketotetrahydrothiofenen; bereiding en reacties

SUMMARY This thesis deals with the synthesis and some reactions of enamines derived from 3-ketotetrahydrothiophenes. Although much work has been done in the field of enamine chemistry, enamines of heterocyclic ketones have been prepared only recently. One of these is the pyrrolidine enamine of 3-ketotetrahydrofuran (see Brannock e tal., 1963) . Only one of the two possible bond isomers was isolated, namely 3-pyrrolidino-2,5dihydro fur an. In view of this it was of interest to examine the formation of enamines from 3-ketotetrahydrothiophenes, ketones which are also of importance in other investigations in this laboratory. Furthermore, since the enamines derived from these ketones are 3-tertaminodihydrothiophenes, they might serve as precursors in the synthesis of new thiophene and tetrahydrothiophene deri vatives. This supposition proved to be correct. ... Zie: Summary