The work described in this thesis is focused on broadening the scope of the enantioselective copper-catalyzed addition of organometallic reagents, in particular organozinc reagents and trimethylaluminum, to the synthesis of several versatile chiral synthons. Particular attention is dedicated to the enantioselective synthesis of N-heterocycles and to their sequential functionalization to form natural products and to the enantioselective synthesis of acyclic α-chiral amines, versatile building blocks for the synthesis of biologically active compounds. Different approaches will be discussed and investigated with particular focus on the use of copper complexes in combination with chiral phosphoramidite ligands.
|Qualification||Doctor of Philosophy|
|Place of Publication||[Groningen]|
|Publication status||Published - 2008|
- Proefschriften (vorm)
- Koperverbindingen, Stereoselectiviteit, Katalysatoren , Kata