Enantioselectivity of a recombinant epoxide hydrolase from Agrobacterium radiobacter

Jeffrey H. Lutje Spelberg; Rick Rink; Richard M. Kellogg; Dick B. Janssen

doi:10.1016/S0957-4166(98)00003-2

Enantioselectivity of a recombinant epoxide hydrolase from Agrobacterium radiobacter

Jeffrey H. Lutje Spelberg, Rick Rink, Richard M. Kellogg, Dick B. Janssen

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Abstract

The recombinant epoxide hydrolase from Agrobacterium radiobacter AD1 was used to obtain enantiomerically pure epoxides by means of a kinetic resolution. Epoxides such as styrene oxide and various derivatives thereof and phenyl glycidyl ether were obtained in high enantiomeric excess and in reasonable yield. The enantioselectivity (E-value) of the resolution was calculated from progress curves for styrene oxide (E=16.2) and para-chlorostyrene oxide (E=32.2). (C) 1998 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	459 - 466
Number of pages	8
Journal	Tetrahedron-Asymmetry
Volume	344
Issue number	9
DOIs	https://doi.org/10.1016/S0957-4166(98)00003-2
Publication status	Published - 13-Feb-1998

Keywords

MICROBIOLOGICAL TRANSFORMATIONS
RESOLUTION
STYRENE
STEREOCHEMISTRY
HYDROLYSIS

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title = "Enantioselectivity of a recombinant epoxide hydrolase from Agrobacterium radiobacter",

abstract = "The recombinant epoxide hydrolase from Agrobacterium radiobacter AD1 was used to obtain enantiomerically pure epoxides by means of a kinetic resolution. Epoxides such as styrene oxide and various derivatives thereof and phenyl glycidyl ether were obtained in high enantiomeric excess and in reasonable yield. The enantioselectivity (E-value) of the resolution was calculated from progress curves for styrene oxide (E=16.2) and para-chlorostyrene oxide (E=32.2). (C) 1998 Elsevier Science Ltd. All rights reserved.",

keywords = "MICROBIOLOGICAL TRANSFORMATIONS, RESOLUTION, STYRENE, STEREOCHEMISTRY, HYDROLYSIS",

author = "{Lutje Spelberg}, {Jeffrey H.} and Rick Rink and Kellogg, {Richard M.} and Janssen, {Dick B.}",

note = "Relation: http://www.rug.nl/scheikunde/ date_submitted:2005 Rights: University of Groningen. Stratingh Institute",

year = "1998",

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doi = "10.1016/S0957-4166(98)00003-2",

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T1 - Enantioselectivity of a recombinant epoxide hydrolase from Agrobacterium radiobacter

AU - Lutje Spelberg, Jeffrey H.

AU - Rink, Rick

AU - Kellogg, Richard M.

AU - Janssen, Dick B.

N1 - Relation: http://www.rug.nl/scheikunde/ date_submitted:2005 Rights: University of Groningen. Stratingh Institute

PY - 1998/2/13

Y1 - 1998/2/13

N2 - The recombinant epoxide hydrolase from Agrobacterium radiobacter AD1 was used to obtain enantiomerically pure epoxides by means of a kinetic resolution. Epoxides such as styrene oxide and various derivatives thereof and phenyl glycidyl ether were obtained in high enantiomeric excess and in reasonable yield. The enantioselectivity (E-value) of the resolution was calculated from progress curves for styrene oxide (E=16.2) and para-chlorostyrene oxide (E=32.2). (C) 1998 Elsevier Science Ltd. All rights reserved.

AB - The recombinant epoxide hydrolase from Agrobacterium radiobacter AD1 was used to obtain enantiomerically pure epoxides by means of a kinetic resolution. Epoxides such as styrene oxide and various derivatives thereof and phenyl glycidyl ether were obtained in high enantiomeric excess and in reasonable yield. The enantioselectivity (E-value) of the resolution was calculated from progress curves for styrene oxide (E=16.2) and para-chlorostyrene oxide (E=32.2). (C) 1998 Elsevier Science Ltd. All rights reserved.

KW - MICROBIOLOGICAL TRANSFORMATIONS

KW - RESOLUTION

KW - STYRENE

KW - STEREOCHEMISTRY

KW - HYDROLYSIS

U2 - 10.1016/S0957-4166(98)00003-2

DO - 10.1016/S0957-4166(98)00003-2

M3 - Article

SN - 0957-4166

VL - 344

SP - 459

EP - 466

JO - Tetrahedron-Asymmetry

JF - Tetrahedron-Asymmetry

IS - 9

ER -

Enantioselectivity of a recombinant epoxide hydrolase from Agrobacterium radiobacter

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