Encapsulation of pancreatic islets for transplantation in diabetes: the untouchable islets

P de Vos*, P Marchetti

*Corresponding author for this work

Research output: Contribution to journalEditorialAcademicpeer-review

128 Citations (Scopus)

Abstract

The aim of encapsulation of pancreatic islets is to transplant in the absence of immunosuppression. It is based on the principle that transplanted tissue is protected from the host immune system by an artificial membrane. Encapsulation allows for application of insulin-secreting cells of animal or other surrogate sources; to overcome human islet shortage. The advantages and pitfalls of the approaches developed so far are discussed and compared, together with some recent progress, in view of applicability in clinical islet transplantation.

Original languageEnglish
Article numberPII S1471-4914(02)02381-X
Pages (from-to)363-366
Number of pages4
JournalTrends in Molecular Medicine
Volume8
Issue number8
Publication statusPublished - Aug-2002

Keywords

  • PORCINE ISLETS
  • IMMUNOSUPPRESSION
  • MICROENCAPSULATION
  • BIOCOMPATIBILITY
  • MICROCAPSULES
  • XENOGRAFTS
  • CYTOKINES
  • SURVIVAL
  • ALGINATE
  • CELLS

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