Abstract
The aim of encapsulation of pancreatic islets is to transplant in the absence of immunosuppression. It is based on the principle that transplanted tissue is protected from the host immune system by an artificial membrane. Encapsulation allows for application of insulin-secreting cells of animal or other surrogate sources; to overcome human islet shortage. The advantages and pitfalls of the approaches developed so far are discussed and compared, together with some recent progress, in view of applicability in clinical islet transplantation.
Original language | English |
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Article number | PII S1471-4914(02)02381-X |
Pages (from-to) | 363-366 |
Number of pages | 4 |
Journal | Trends in Molecular Medicine |
Volume | 8 |
Issue number | 8 |
Publication status | Published - Aug-2002 |
Keywords
- PORCINE ISLETS
- IMMUNOSUPPRESSION
- MICROENCAPSULATION
- BIOCOMPATIBILITY
- MICROCAPSULES
- XENOGRAFTS
- CYTOKINES
- SURVIVAL
- ALGINATE
- CELLS