Endocrine disrupting chemicals during diet-induced weight loss - A post-hoc analysis of the LOWER study

Thomas P. van der Meer, Chris H. L. Thio, Martijn van Faassen, Andre P. van Beek, Harold Snieder, Frank N. R. van Berkum, Ido P. Kema, Konstantinos C. Makris, Bruce H. R. Wolffenbuttel*, Jana V. van Vliet-Ostaptchouk*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The link between exposure to endocrine disrupting chemicals (EDCs) and the rapid increase in prevalence of obesity has recently been suggested. However, the magnitude and health impact of EDC exposure in at-risk populations remain largely unclear. In this study, we investigated the effect of a dietary intervention driven reduction in adipose tissue on the magnitude of urinary EDC exposure and mobilization, and whether higher EDC exposure leads to impaired weight loss in obese individuals. In this post-hoc analysis of the Lifestyle, OverWeight, Energy Restriction (LOWER) study from the Netherlands, 218 subjects were included. Five parabens, three bisphenols and thirteen metabolites of eight phthalates were measured in 24-h urine using LC-MS/MS, before and after three-months of a calory-restricted weight reduction intervention program. Associations between adiposity-related traits and EDCs were tested using multivariable linear regression and linear mixed effects models. A multiple testing correction based on the false discovery rate (FDR) was applied. After the 3-month intervention, urinary paraben and bisphenol excretions remained similar. Excretions of mono-butyl phthalates and most high-molecular-weight phthalates decreased, whereas mono-ethyl phthalate increased (all FDR

Original languageEnglish
Article number110262
Number of pages9
JournalEnvironmental Research
Volume192
DOIs
Publication statusPublished - Jan-2021

Keywords

  • Endocrine disrupting chemicals
  • Obesity
  • Diet-induced weight loss
  • Intervention
  • Obesogenic
  • NONPERSISTENT ENVIRONMENTAL CHEMICALS
  • URINARY PHTHALATE METABOLITES
  • BISPHENOL-A
  • INSULIN-RESISTANCE
  • BODY BURDEN
  • PARABENS
  • EXCRETION
  • EXPOSURE
  • CHILDREN
  • HUMANS

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