Energy metabolisme and brain damage: Investigations by positron emission tomography (PET); the role of ketone bodies in cerebral protection

Gerardus Hyacinthus Maria Prenen

Research output: ThesisThesis fully internal (DIV)

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Abstract

In a general sense this thesis comprises three subjects: a) the changes in energy metabolism of the brain during cerebral pathology, b) the effect of alterations in energy metabolism on the extent of brain damage, and c) measures to prevent or limit brain damage. In this context the formation of brain damage and possible restorative processes are studied in two models of cerebral pathology: a) a (modified) Levine model of hypoxic and ischemic brain damage in rats, and b) the freezing lesion in cats; the latter is a model of disruption of the blood-brain barrier (BBB) and formation of vasogenic brain edema. Furthermore, some methods to protect the brain against (hypoxic-ischemic) brain damage are evaluated. ... Zie: Summary
Original languageEnglish
QualificationDoctor of Philosophy
Supervisors/Advisors
  • Korf, Jakob, Supervisor
  • Vaalburg, Willem, Supervisor
Publisher
Publication statusPublished - 1992

Keywords

  • Proefschriften (vorm)
  • Positronemissietomografie
  • Energiestofwisseling, Hersenbeschadiging,
  • neurologie

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