Enhance cell-material interaction for ingrowth of eptfe-sleeved cardiovascular stent based on physicochemical surface properties

Richard Hamstra; Patrick van Rijn; Klaudia Jurczak; Richte Schuurmann; Jean-Paul P. M. de Vries

Enhance cell-material interaction for ingrowth of eptfe-sleeved cardiovascular stent based on physicochemical surface properties

Richard Hamstra (Inventor), Patrick van Rijn (Inventor), Klaudia Jurczak (Inventor), Richte Schuurmann (Inventor), Jean-Paul P. M. de Vries (Inventor)

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Abstract

The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to enhance the attachment and ingrowth of ePTFE sleeved stents with the blood vessel wall. The specific physicochemical properties stimulate smooth muscle cell attachment and spreading that enables the stent to be biologically fixated in a very intimate fashion. This biological fixation prevents migration, infection, and aneurysm progression.

Original language	English
Patent number	WO2025153322
Priority date	19/01/2024
Filing date	20/01/2025
Publication status	Published - 24-Jul-2025

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title = "Enhance cell-material interaction for ingrowth of eptfe-sleeved cardiovascular stent based on physicochemical surface properties",

abstract = "The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to enhance the attachment and ingrowth of ePTFE sleeved stents with the blood vessel wall. The specific physicochemical properties stimulate smooth muscle cell attachment and spreading that enables the stent to be biologically fixated in a very intimate fashion. This biological fixation prevents migration, infection, and aneurysm progression.",

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T1 - Enhance cell-material interaction for ingrowth of eptfe-sleeved cardiovascular stent based on physicochemical surface properties

AU - Hamstra, Richard

AU - van Rijn, Patrick

AU - Jurczak, Klaudia

AU - Schuurmann, Richte

AU - de Vries, Jean-Paul P. M.

PY - 2025/7/24

Y1 - 2025/7/24

N2 - The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to enhance the attachment and ingrowth of ePTFE sleeved stents with the blood vessel wall. The specific physicochemical properties stimulate smooth muscle cell attachment and spreading that enables the stent to be biologically fixated in a very intimate fashion. This biological fixation prevents migration, infection, and aneurysm progression.

AB - The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to enhance the attachment and ingrowth of ePTFE sleeved stents with the blood vessel wall. The specific physicochemical properties stimulate smooth muscle cell attachment and spreading that enables the stent to be biologically fixated in a very intimate fashion. This biological fixation prevents migration, infection, and aneurysm progression.

M3 - Patent

M1 - WO2025153322

Y2 - 2025/01/20

ER -

Enhance cell-material interaction for ingrowth of eptfe-sleeved cardiovascular stent based on physicochemical surface properties

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