TY - JOUR
T1 - Enhancement and Comparison of (Ceftazidime-)Avibactam Plus Aztreonam Susceptibility Tests for Stenotrophomonas maltophilia in Clinical Diagnostics
AU - Vlaspolder, Gro L.
AU - Hughes, Laura A.
AU - Huis in ’t Veld, Robert A.G.
AU - Kampinga, Greetje A.
AU - Bathoorn, Erik
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2024/1
Y1 - 2024/1
N2 - Stenotrophomonas maltophilia is naturally resistant to many antimicrobials. We evaluated the in vitro activity and reproducibility of two different super-position methods of aztreonam in combination with ceftazidime-avibactam for S. maltophilia and compared these results with the recently available aztreonam-avibactam gradient strip. We recommend an improved super-position method that avoids the possible risk of handling a contaminated aztreonam strip. In addition, we report that the cefazidime-avibactam and aztreonam super-position method showed increased in vitro activity in comparison with aztreonam-avibactam indicating activity of the ceftazidime component in vitro.
AB - Stenotrophomonas maltophilia is naturally resistant to many antimicrobials. We evaluated the in vitro activity and reproducibility of two different super-position methods of aztreonam in combination with ceftazidime-avibactam for S. maltophilia and compared these results with the recently available aztreonam-avibactam gradient strip. We recommend an improved super-position method that avoids the possible risk of handling a contaminated aztreonam strip. In addition, we report that the cefazidime-avibactam and aztreonam super-position method showed increased in vitro activity in comparison with aztreonam-avibactam indicating activity of the ceftazidime component in vitro.
UR - http://www.scopus.com/inward/record.url?scp=85178465453&partnerID=8YFLogxK
U2 - 10.1007/s00284-023-03530-7
DO - 10.1007/s00284-023-03530-7
M3 - Article
C2 - 38051338
AN - SCOPUS:85178465453
SN - 0343-8651
VL - 81
JO - Current Microbiology
JF - Current Microbiology
M1 - 28
ER -