Enhancing the antimicrobial potential of lanthipeptides by employing different engineering strategies

Research output: ThesisThesis fully internal (DIV)

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Abstract

The research described in this thesis aimed to develop novel approaches to engineer lantibiotics, to control either planktonic pathogens or biofilm-infections. To expand the toolbox of engineering lantibiotics, this thesis furthermore aimed at generating a method for obtaining lanthipeptide synthetases with adapted substrate specificity by directed evolution.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • Kuipers, Oscar, Supervisor
  • Moll, Gert, Supervisor
Award date22-Jun-2020
Place of Publication[Groningen]
Publisher
Print ISBNs9789403427836
Electronic ISBNs9789403427843
DOIs
Publication statusPublished - 2020

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