EORTC 24051: Unexpected side effects in a phase I study of TPF induction chemotherapy followed by chemoradiation with lapatinib, a dual EGFR/ErbB2 inhibitor, in patients with locally advanced resectable larynx and hypopharynx squamous cell carcinoma

Yassine Lalami*, Pol M. Specenier, Ahmad Awada, Denis Lacombe, Cecilia Liberatoscioli, Catherine Fortpied, Iman El-Hariry, Jan Bogaerts, Guy Andry, J. A. Langendijk, Jan B. Vermorken

*Corresponding author for this work

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Abstract

Background: In this phase I/II study, the addition of lapatinib (LAP) was investigated in combination with the sequential use of both approaches TPF induction chemotherapy (ICT) followed by chemoradiation (CRT) in locally advanced larynx or hypopharynx squamous cell carcinoma. Patients and methods: Objectives were to assess maximum tolerated dose, dose-limiting toxicity (DLT) and to recommend a safe dose of LAP when administered with 4 cycles of TPF followed by CRT. Results: Seven male patients were included. Three patients were included in the first cohort, at dose level 1 (LAP 500 mg daily plus TPF). Renal toxicity was observed among these three patients (grade 3 [n =1], grade 2 In =1] and grade 1 [n = 1]), with 1 DLT, leading to treatment interruption. in this group. Nephrotoxicity was reversible after stopping LAP and hydration of the patients. In a second cohort of four patients administering docetaxel from the second cycle, 3 more DLTs were observed (grade 2 renal toxicity and grade 3 diarrhea, grade 3 anorexia and grade 3 stomatitis, and grade 4 neutropenia). Based on the occurrence of 4 DLTs at the first dose level of LAP, patient recruitment was closed. Conclusion: These data indicate that LAP cannot be combined safely with full dose TPF. (C) 2012 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 105 (2012) 238-240

Original languageEnglish
Pages (from-to)238-240
Number of pages3
JournalRadiotherapy and Oncology
Volume105
Issue number2
DOIs
Publication statusPublished - Nov-2012

Keywords

  • Lapatinib
  • Head and neck cancer
  • Induction chemotherapy
  • Chemoradiation
  • GROWTH-FACTOR RECEPTOR
  • NECK-CANCER
  • CONCURRENT CHEMORADIATION
  • ORGAN PRESERVATION
  • ADVANCED HEAD
  • DOCETAXEL
  • CISPLATIN
  • SURVIVAL
  • FLUOROURACIL
  • RADIOTHERAPY

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