EpCAM Expression in Lymph Node and Bone Metastases of Prostate Carcinoma: A Pilot Study

Anna K. Campos, Hilde D. Hoving*, Stefano Rosati, Geert J. L. H. van Leenders, Igle J. de Jong

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
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Abstract

There is an urgent need for new imaging modalities in prostate carcinoma staging. A non-invasive modality that can assess lymph node and bone metastases simultaneously is preferred. Epithelial cell adhesion molecule (EpCAM) is a membranous protein of interest as an imaging target since it is overexpressed in prostatic carcinoma compared with benign prostate epithelium and compared with stroma. However, EpCAM expression in lymph node metastases is sparsely available in the literature and EpCAM expression in bone metastases is yet unknown. The current study evaluates the expression of EpCAM in prostate carcinoma lymph nodes, in matched normal lymph nodes, in prostate carcinoma bone metastases, and in normal bone by immunohistochemistry. EpCAM was expressed in 100% of lymph node metastases (21 out of 21), in 0% of normal lymph nodes (0 out of 21), in 95% of bone metastases (19 out of 20), and in 0% of normal bone (0 out of 14). Based on these results, EpCAM may be a feasible imaging target in prostate carcinoma lymph node and bone metastases. Prospective clinical trials are needed to confirm current results. Preoperative visualization of prostate carcinoma metastases will improve disease staging and will prevent unnecessary invasive surgery.

Original languageEnglish
Article number1650
Number of pages9
JournalInternational Journal of Molecular Sciences
Volume17
Issue number10
DOIs
Publication statusPublished - 29-Sep-2016

Keywords

  • molecular imaging
  • imaging target
  • prostate carcinoma
  • metastases
  • epithelial cell adhesion molecule (EpCAM)
  • immunohistochemistry
  • CELL ADHESION MOLECULE
  • EP-CAM
  • RADICAL PROSTATECTOMY
  • CANCER
  • TARGETS
  • PET/CT
  • NIRF

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