Epidemic and pandemic viral infections: impact on tuberculosis and the lung

Catherine Wei Min Ong, Giovanni Battista Migliori, Mario Raviglione, Gavin MacGregor-Skinner, Giovanni Sotgiu, Jan-Willem Alffenaar, Simon Tiberi, Cornelia Adlhoch, Tonino Alonzi, Sophia Archuleta, Sergio Brusin, Emmanuelle Cambau, Maria Rosaria Capobianchi, Concetta Castilletti, Rosella Centis, Daniela M. Cirillo, Lia D'Ambrosio, Giovanni Delogu, Susanna M. R. Esposito, Jose FigueroaJon S. Friedland, Benjamin Choon Heng Ho, Giuseppe Ippolito, Mateja Jankovic, Hannah Yejin Kim, Senia Rosales Klintz, Csaba Kodmon, Eleonora Lalle, Yee Sin Leo, Chi-Chiu Leung, Anne-Grete Martson, Mario Giovanni Melazzini, Saeid Najafi Fard, Pasi Penttinen, Linda Petrone, Elisa Petruccioli, Emanuele Pontali, Laura Saderi, Miguel Santin, Antonio Spanevello, Reinout van Crevel, Marieke J. van der Werf, Dina Visca, Miguel Viveiros, Jean-Pierre Zellweger, Alimuddin Zumla, Delia Goletti

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    Abstract

    Major epidemics, including some that qualify as pandemics, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A (H1N1)pdm/09 and most recently COVID-19, affect the lung. Tuberculosis (TB) remains the top infectious disease killer, but apart from syndemic TB/HIV little is known regarding the interaction of viral epidemics and pandemics with TB. The aim of this consensus-based document is to describe the effects of viral infections resulting in epidemics and pandemics that affect the lung (MERS, SARS, HIV, influenza A (H1N1)pdm/09 and COVID-19) and their interactions with TB. A search of the scientific literature was performed. A writing committee of international experts including the European Centre for Disease Prevention and Control Public Health Emergency (ECDC PHE) team, the World Association for Infectious Diseases and Immunological Disorders (WAidid), the Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycobacterial Infections (ESGMYC) was established. Consensus was achieved after multiple rounds of revisions between the writing committee and a larger expert group. A Delphi process involving the core group of authors (excluding the ECDC PHE team) identified the areas requiring review/consensus, followed by a second round to refine the definitive consensus elements. The epidemiology and immunology of these viral infections and their interactions with TB are discussed with implications for diagnosis, treatment and prevention of airborne infections (infection control, viral containment and workplace safety). This consensus document represents a rapid and comprehensive summary on what is known on the topic.

    Original languageEnglish
    Number of pages55
    JournalEuropean Respiratory Journal
    Volume56
    Issue number4
    DOIs
    Publication statusPublished - 1-Oct-2020

    Keywords

    • EAST RESPIRATORY SYNDROME
    • PNEUMONIA REQUIRING HOSPITALIZATION
    • INFLUENZA-VIRUS INFECTION
    • EFFECTOR MEMORY PHENOTYPE
    • CRITICALLY-ILL PATIENTS
    • ANTIVIRAL DRUG ARBIDOL
    • T-CELL RESPONSES
    • MYCOBACTERIUM-TUBERCULOSIS
    • SYNDROME CORONAVIRUS
    • BACTERIAL PNEUMONIA

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