Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China

Xin Huang; Ilja Nolte; Zifen Gao; Hans Vos; Bouke Hepkema; Sibrand Poppema; Anke van den Berg; Arjan Diepstra

doi:10.1371/journal.pone.0021152

Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China

Xin Huang^*, Ilja Nolte, Zifen Gao, Hans Vos, Bouke Hepkema, Sibrand Poppema, Anke van den Berg, Arjan Diepstra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: The incidence of classical Hodgkin lymphoma (cHL) and its association with Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location. This is the first report on epidemiological features of cHL patients from Northern regions of China. These features are compared to data from a previously published Dutch cHL population.

Methodology/Principal Findings: 157 cHL patients diagnosed between 1997 and 2008 in the North of China were included after histopathological re-evaluation. The Dutch population-based cohort consisted of 515 cHL patients diagnosed between 1987 and 2000. EBV status was determined by in situ hybridization of EBV-encoded small RNAs. In the Chinese population, tumor cells of 39% of the cHL patients were EBV+ and this was significantly associated with male sex, mixed cellularity subtype and young age (

Conclusion/Significance: CHL patients from Northern regions of China show a distinctive age distribution pattern with a striking incidence peak of EBV+ mixed cellularity cases among children and adolescents and another high incidence peak of EBV-nodular sclerosis cases in young adults. In comparison to Dutch cHL patients there are pronounced differences in age distribution, subtype and EBV status, presumably caused by complex gene-environmental interactions.

Original language	English
Article number	21152
Number of pages	6
Journal	PLoS ONE
Volume	6
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0021152
Publication status	Published - 10-Jun-2011

Keywords

CLINICAL CHARACTERISTICS
DISEASE
INFECTION
POPULATION
TAIWAN
ADULT
EBV
EXPRESSION
SUBTYPE
BRAZIL

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Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern ChinaFinal publisher's version, 184 KBLicence: CC BY

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@article{71e0cfe64b8540d0bb16446a62bdc225,

title = "Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China",

abstract = "Background: The incidence of classical Hodgkin lymphoma (cHL) and its association with Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location. This is the first report on epidemiological features of cHL patients from Northern regions of China. These features are compared to data from a previously published Dutch cHL population.Methodology/Principal Findings: 157 cHL patients diagnosed between 1997 and 2008 in the North of China were included after histopathological re-evaluation. The Dutch population-based cohort consisted of 515 cHL patients diagnosed between 1987 and 2000. EBV status was determined by in situ hybridization of EBV-encoded small RNAs. In the Chinese population, tumor cells of 39% of the cHL patients were EBV+ and this was significantly associated with male sex, mixed cellularity subtype and young age (Conclusion/Significance: CHL patients from Northern regions of China show a distinctive age distribution pattern with a striking incidence peak of EBV+ mixed cellularity cases among children and adolescents and another high incidence peak of EBV-nodular sclerosis cases in young adults. In comparison to Dutch cHL patients there are pronounced differences in age distribution, subtype and EBV status, presumably caused by complex gene-environmental interactions.",

keywords = "CLINICAL CHARACTERISTICS, DISEASE, INFECTION, POPULATION, TAIWAN, ADULT, EBV, EXPRESSION, SUBTYPE, BRAZIL",

author = "Xin Huang and Ilja Nolte and Zifen Gao and Hans Vos and Bouke Hepkema and Sibrand Poppema and {van den Berg}, Anke and Arjan Diepstra",

year = "2011",

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doi = "10.1371/journal.pone.0021152",

language = "English",

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T1 - Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China

AU - Huang, Xin

AU - Nolte, Ilja

AU - Gao, Zifen

AU - Vos, Hans

AU - Hepkema, Bouke

AU - Poppema, Sibrand

AU - van den Berg, Anke

AU - Diepstra, Arjan

PY - 2011/6/10

Y1 - 2011/6/10

N2 - Background: The incidence of classical Hodgkin lymphoma (cHL) and its association with Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location. This is the first report on epidemiological features of cHL patients from Northern regions of China. These features are compared to data from a previously published Dutch cHL population.Methodology/Principal Findings: 157 cHL patients diagnosed between 1997 and 2008 in the North of China were included after histopathological re-evaluation. The Dutch population-based cohort consisted of 515 cHL patients diagnosed between 1987 and 2000. EBV status was determined by in situ hybridization of EBV-encoded small RNAs. In the Chinese population, tumor cells of 39% of the cHL patients were EBV+ and this was significantly associated with male sex, mixed cellularity subtype and young age (Conclusion/Significance: CHL patients from Northern regions of China show a distinctive age distribution pattern with a striking incidence peak of EBV+ mixed cellularity cases among children and adolescents and another high incidence peak of EBV-nodular sclerosis cases in young adults. In comparison to Dutch cHL patients there are pronounced differences in age distribution, subtype and EBV status, presumably caused by complex gene-environmental interactions.

AB - Background: The incidence of classical Hodgkin lymphoma (cHL) and its association with Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location. This is the first report on epidemiological features of cHL patients from Northern regions of China. These features are compared to data from a previously published Dutch cHL population.Methodology/Principal Findings: 157 cHL patients diagnosed between 1997 and 2008 in the North of China were included after histopathological re-evaluation. The Dutch population-based cohort consisted of 515 cHL patients diagnosed between 1987 and 2000. EBV status was determined by in situ hybridization of EBV-encoded small RNAs. In the Chinese population, tumor cells of 39% of the cHL patients were EBV+ and this was significantly associated with male sex, mixed cellularity subtype and young age (Conclusion/Significance: CHL patients from Northern regions of China show a distinctive age distribution pattern with a striking incidence peak of EBV+ mixed cellularity cases among children and adolescents and another high incidence peak of EBV-nodular sclerosis cases in young adults. In comparison to Dutch cHL patients there are pronounced differences in age distribution, subtype and EBV status, presumably caused by complex gene-environmental interactions.

KW - CLINICAL CHARACTERISTICS

KW - DISEASE

KW - INFECTION

KW - POPULATION

KW - TAIWAN

KW - ADULT

KW - EBV

KW - EXPRESSION

KW - SUBTYPE

KW - BRAZIL

U2 - 10.1371/journal.pone.0021152

DO - 10.1371/journal.pone.0021152

M3 - Article

SN - 1932-6203

VL - 6

JO - PLoS ONE

JF - PLoS ONE

IS - 6

M1 - 21152

ER -

Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China

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