Epigenetic differences between sister chromatids?

Peter M. Lansdorp*, Ester Falconer, Jiang Tao, Julie Brind'Amour, Ulrike Naumann

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

16 Citations (Scopus)

Abstract

Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear. Many chromatin marks are likely to be copied onto both sister chromatids in conjunction with DNA replication, whereas others could be distributed randomly between sister chromatids. Epigenetic differences between sister chromatids could also emerge in a more predictable manner, for example, following processes that are associated with lagging strand DNA replication. The resulting epigenetic differences between sister chromatids could result in different gene expression patterns in daughter cells. This possibility has been difficult to test because techniques to distinguish between parental sister chromatids require analysis of single cells and are not obvious. Here, we briefly review the topic of sister chromatid epigenetics and discuss how the identification of sister chromatids in cells could change the way we think about asymmetric cell divisions and stochastic variation in gene expression between cells in general and paired daughter cells in particular.

Original languageEnglish
Title of host publicationHEMATOPOIETIC STEM CELLS VIII
EditorsL Kanz, WE Fibbe, C Lengerke, JE Dick
Place of PublicationOXFORD
PublisherBlackwell Publishing
Pages1-6
Number of pages6
ISBN (Print)978-1-57331-867-9
DOIs
Publication statusPublished - 2012
Event8th International Conference and Workshop on Hematopoietic Stem Cells - , Germany
Duration: 22-Sep-201124-Sep-2011

Publication series

NameAnnals of the New York Academy of Sciences
PublisherBLACKWELL SCIENCE PUBL
Volume1266
ISSN (Print)0077-8923

Other

Other8th International Conference and Workshop on Hematopoietic Stem Cells
CountryGermany
Period22/09/201124/09/2011

Keywords

  • DNA replication
  • chromatin
  • epigenetic marks
  • sister chromatids
  • ADENOMATOUS POLYPOSIS-COLI
  • TEMPLATE DNA STRANDS
  • APC TUMOR-SUPPRESSOR
  • EMBRYONIC STEM-CELLS
  • SELECTIVE SEGREGATION
  • METHYLATION
  • DIVISION
  • IDENTIFICATION
  • CHROMOSOMES
  • TRANSCRIPTS

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