@inproceedings{b05b9c7add5c478693b05db0345f80e5,
title = "Epigenetic differences between sister chromatids?",
abstract = "Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear. Many chromatin marks are likely to be copied onto both sister chromatids in conjunction with DNA replication, whereas others could be distributed randomly between sister chromatids. Epigenetic differences between sister chromatids could also emerge in a more predictable manner, for example, following processes that are associated with lagging strand DNA replication. The resulting epigenetic differences between sister chromatids could result in different gene expression patterns in daughter cells. This possibility has been difficult to test because techniques to distinguish between parental sister chromatids require analysis of single cells and are not obvious. Here, we briefly review the topic of sister chromatid epigenetics and discuss how the identification of sister chromatids in cells could change the way we think about asymmetric cell divisions and stochastic variation in gene expression between cells in general and paired daughter cells in particular.",
keywords = "DNA replication, chromatin, epigenetic marks, sister chromatids, ADENOMATOUS POLYPOSIS-COLI, TEMPLATE DNA STRANDS, APC TUMOR-SUPPRESSOR, EMBRYONIC STEM-CELLS, SELECTIVE SEGREGATION, METHYLATION, DIVISION, IDENTIFICATION, CHROMOSOMES, TRANSCRIPTS",
author = "Lansdorp, {Peter M.} and Ester Falconer and Jiang Tao and Julie Brind'Amour and Ulrike Naumann",
year = "2012",
doi = "10.1111/j.1749-6632.2012.06505.x",
language = "English",
isbn = "978-1-57331-867-9",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing",
pages = "1--6",
editor = "L Kanz and WE Fibbe and C Lengerke and JE Dick",
booktitle = "HEMATOPOIETIC STEM CELLS VIII",
note = "8th International Conference and Workshop on Hematopoietic Stem Cells ; Conference date: 22-09-2011 Through 24-09-2011",
}