Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

Angelina Osipyan; Deng Chen; Frank J. Dekker

doi:10.1016/j.drudis.2021.03.012

Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

Angelina Osipyan, Deng Chen, Frank J. Dekker^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Epigenetic mechanisms are important for the regular development and maintenance of the tissue-specific expression of cytokine genes. One of the crucial cytokines involved in cancer and inflammation is macrophage migration inhibitory factor (MIF), which triggers the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways by binding to CD74 and other receptors. Altered expression of this cytokine and altered activity states of the connected pathways are linked to inflammatory disease and cancer. Therapeutic strategies based on epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.

Original language	English
Pages (from-to)	1728-1734
Journal	Drug Discovery Today
Volume	26
Issue number	7
Early online date	18-Mar-2021
DOIs	https://doi.org/10.1016/j.drudis.2021.03.012
Publication status	Published - Jul-2021

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title = "Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation",

abstract = "Epigenetic mechanisms are important for the regular development and maintenance of the tissue-specific expression of cytokine genes. One of the crucial cytokines involved in cancer and inflammation is macrophage migration inhibitory factor (MIF), which triggers the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways by binding to CD74 and other receptors. Altered expression of this cytokine and altered activity states of the connected pathways are linked to inflammatory disease and cancer. Therapeutic strategies based on epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.",

author = "Angelina Osipyan and Deng Chen and Dekker, {Frank J.}",

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AU - Osipyan, Angelina

AU - Chen, Deng

AU - Dekker, Frank J.

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Y1 - 2021/7

N2 - Epigenetic mechanisms are important for the regular development and maintenance of the tissue-specific expression of cytokine genes. One of the crucial cytokines involved in cancer and inflammation is macrophage migration inhibitory factor (MIF), which triggers the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways by binding to CD74 and other receptors. Altered expression of this cytokine and altered activity states of the connected pathways are linked to inflammatory disease and cancer. Therapeutic strategies based on epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.

AB - Epigenetic mechanisms are important for the regular development and maintenance of the tissue-specific expression of cytokine genes. One of the crucial cytokines involved in cancer and inflammation is macrophage migration inhibitory factor (MIF), which triggers the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways by binding to CD74 and other receptors. Altered expression of this cytokine and altered activity states of the connected pathways are linked to inflammatory disease and cancer. Therapeutic strategies based on epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.

U2 - 10.1016/j.drudis.2021.03.012

DO - 10.1016/j.drudis.2021.03.012

M3 - Review article

C2 - 33746067

SN - 1359-6446

VL - 26

SP - 1728

EP - 1734

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 7

ER -

Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

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