Erythrocyte membrane fatty acids in benign and progressive forms of multiple sclerosis

M Koch; GSM Ramsaransing; MR Fokkema; DJ Heersema; J De Keyser

doi:10.1016/j.jns.2006.01.010

Erythrocyte membrane fatty acids in benign and progressive forms of multiple sclerosis

M Koch^*, GSM Ramsaransing, MR Fokkema, DJ Heersema, J De Keyser

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

BACKGROUND: There is no good explanation why a proportion of patients with multiple sclerosis (MS) have a relatively benign form of the disease. An imbalance between saturated and unsaturated fatty acids (FA) might influence the disease course of MS.

AIM: To assess whether the erythrocyte membrane fatty acid composition, which is a biological marker of long term dietary FA consumption, is different between patients with benign and progressive MS.

METHODS: The erythrocyte membrane FA composition was measured by gas chromatography in 23 healthy controls, 27 patients with benign MS, 32 patients with secondary progressive MS and 23 patients with primary progressive MS. None of the patients was following a special diet.

RESULTS: No significant differences in levels of saturated and unsaturated FA or in omega-3- and omega-6-polyunsaturated FA were found between controls and patients with the different subtypes of MS.

CONCLUSION: Our data suggest that factors other than dietary fatty acid consumption are responsible for the different disease courses of MS.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume	244
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2006.01.010
Publication status	Published - 15-May-2006

Keywords

multiple sclerosis
benign multiple sclerosis
polyunsaturated fatty acids
LINOLEIC-ACID
ALLERGIC ENCEPHALOMYELITIS
METHYL-ESTERS
WHITE MATTER
BLOOD-CELLS
PLASMA
CHAIN
RISK

Access to Document

10.1016/j.jns.2006.01.010

Erythrocyte membrane fatty acids in benign and progressive forms of multiple sclerosisFinal publisher's version, 83.9 KBLicence: Taverne

Handle.net

Persistent link

Cite this

@article{c1002426a7ec42a09980ea9b0b32a1e6,

title = "Erythrocyte membrane fatty acids in benign and progressive forms of multiple sclerosis",

abstract = "BACKGROUND: There is no good explanation why a proportion of patients with multiple sclerosis (MS) have a relatively benign form of the disease. An imbalance between saturated and unsaturated fatty acids (FA) might influence the disease course of MS.AIM: To assess whether the erythrocyte membrane fatty acid composition, which is a biological marker of long term dietary FA consumption, is different between patients with benign and progressive MS.METHODS: The erythrocyte membrane FA composition was measured by gas chromatography in 23 healthy controls, 27 patients with benign MS, 32 patients with secondary progressive MS and 23 patients with primary progressive MS. None of the patients was following a special diet.RESULTS: No significant differences in levels of saturated and unsaturated FA or in omega-3- and omega-6-polyunsaturated FA were found between controls and patients with the different subtypes of MS.CONCLUSION: Our data suggest that factors other than dietary fatty acid consumption are responsible for the different disease courses of MS.",

keywords = "multiple sclerosis, benign multiple sclerosis, polyunsaturated fatty acids, LINOLEIC-ACID, ALLERGIC ENCEPHALOMYELITIS, METHYL-ESTERS, WHITE MATTER, BLOOD-CELLS, PLASMA, CHAIN, RISK",

author = "M Koch and GSM Ramsaransing and MR Fokkema and DJ Heersema and {De Keyser}, J",

note = "Article J",

year = "2006",

month = may,

day = "15",

doi = "10.1016/j.jns.2006.01.010",

language = "English",

volume = "244",

pages = "123--126",

journal = "JOURNAL OF THE NEUROLOGICAL SCIENCES",

issn = "0022-510X",

publisher = "ELSEVIER SCIENCE BV",

number = "1-2",

}

TY - JOUR

T1 - Erythrocyte membrane fatty acids in benign and progressive forms of multiple sclerosis

AU - Koch, M

AU - Ramsaransing, GSM

AU - Fokkema, MR

AU - Heersema, DJ

AU - De Keyser, J

N1 - Article J

PY - 2006/5/15

Y1 - 2006/5/15

N2 - BACKGROUND: There is no good explanation why a proportion of patients with multiple sclerosis (MS) have a relatively benign form of the disease. An imbalance between saturated and unsaturated fatty acids (FA) might influence the disease course of MS.AIM: To assess whether the erythrocyte membrane fatty acid composition, which is a biological marker of long term dietary FA consumption, is different between patients with benign and progressive MS.METHODS: The erythrocyte membrane FA composition was measured by gas chromatography in 23 healthy controls, 27 patients with benign MS, 32 patients with secondary progressive MS and 23 patients with primary progressive MS. None of the patients was following a special diet.RESULTS: No significant differences in levels of saturated and unsaturated FA or in omega-3- and omega-6-polyunsaturated FA were found between controls and patients with the different subtypes of MS.CONCLUSION: Our data suggest that factors other than dietary fatty acid consumption are responsible for the different disease courses of MS.

AB - BACKGROUND: There is no good explanation why a proportion of patients with multiple sclerosis (MS) have a relatively benign form of the disease. An imbalance between saturated and unsaturated fatty acids (FA) might influence the disease course of MS.AIM: To assess whether the erythrocyte membrane fatty acid composition, which is a biological marker of long term dietary FA consumption, is different between patients with benign and progressive MS.METHODS: The erythrocyte membrane FA composition was measured by gas chromatography in 23 healthy controls, 27 patients with benign MS, 32 patients with secondary progressive MS and 23 patients with primary progressive MS. None of the patients was following a special diet.RESULTS: No significant differences in levels of saturated and unsaturated FA or in omega-3- and omega-6-polyunsaturated FA were found between controls and patients with the different subtypes of MS.CONCLUSION: Our data suggest that factors other than dietary fatty acid consumption are responsible for the different disease courses of MS.

KW - multiple sclerosis

KW - benign multiple sclerosis

KW - polyunsaturated fatty acids

KW - LINOLEIC-ACID

KW - ALLERGIC ENCEPHALOMYELITIS

KW - METHYL-ESTERS

KW - WHITE MATTER

KW - BLOOD-CELLS

KW - PLASMA

KW - CHAIN

KW - RISK

U2 - 10.1016/j.jns.2006.01.010

DO - 10.1016/j.jns.2006.01.010

M3 - Article

C2 - 16519904

SN - 0022-510X

VL - 244

SP - 123

EP - 126

JO - JOURNAL OF THE NEUROLOGICAL SCIENCES

JF - JOURNAL OF THE NEUROLOGICAL SCIENCES

IS - 1-2

ER -

Erythrocyte membrane fatty acids in benign and progressive forms of multiple sclerosis

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this