Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survival

Hendrik Folkerts; Carin L. E. Hazenberg; Ewout J. Houwerzijl; Fiona A. J. van den Heuvel; Andre B. Mulder; Johannes J. L. van der Want; Edo Vellenga

doi:10.1016/j.exphem.2014.11.005

Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survival

Hendrik Folkerts, Carin L. E. Hazenberg, Ewout J. Houwerzijl, Fiona A. J. van den Heuvel, Andre B. Mulder, Johannes J. L. van der Want, Edo Vellenga^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

To investigate whether the type of programmed cell death of myelodysplastic erythroid cells depends on their cellular context, we performed studies on cells from patients with low-risk myelodysplastic syndromes. We compared erythroid cells (and their precursor cells) from the mononuclear cell fraction with those from the hematon fraction, which are compacted complexes of hematopoietic cells surrounded by their own micro-environment. In directly fixed materials, erythroblasts exhibited signs of autophagy with limited apoptosis (

Original language	English
Pages (from-to)	215-222.e2
Number of pages	10
Journal	Experimental Hematology
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.exphem.2014.11.005
Publication status	Published - Mar-2015

Keywords

MESENCHYMAL STROMAL CELLS
ACUTE MYELOID-LEUKEMIA
BONE-MARROW
ENHANCED AUTOPHAGY
STEM-CELL
MEGAKARYOCYTES
PRECURSORS
HEMATON
UNIT

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Erythroid progenitors from patients with low-risk myelodysplastic syndromes
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Folkerts, H., Hazenberg, C. L. E., Houwerzijl, E. J., van den Heuvel, F. A. J., Mulder, A. B., van der Want, J. J. L., & Vellenga, E. (2015). Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survival. Experimental Hematology, 43(3), 215-222.e2. https://doi.org/10.1016/j.exphem.2014.11.005

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abstract = "To investigate whether the type of programmed cell death of myelodysplastic erythroid cells depends on their cellular context, we performed studies on cells from patients with low-risk myelodysplastic syndromes. We compared erythroid cells (and their precursor cells) from the mononuclear cell fraction with those from the hematon fraction, which are compacted complexes of hematopoietic cells surrounded by their own micro-environment. In directly fixed materials, erythroblasts exhibited signs of autophagy with limited apoptosis (",

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AU - Folkerts, Hendrik

AU - Hazenberg, Carin L. E.

AU - Houwerzijl, Ewout J.

AU - van den Heuvel, Fiona A. J.

AU - Mulder, Andre B.

AU - van der Want, Johannes J. L.

AU - Vellenga, Edo

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KW - ACUTE MYELOID-LEUKEMIA

KW - BONE-MARROW

KW - ENHANCED AUTOPHAGY

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KW - MEGAKARYOCYTES

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