Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survival

Hendrik Folkerts, Carin L. E. Hazenberg, Ewout J. Houwerzijl, Fiona A. J. van den Heuvel, Andre B. Mulder, Johannes J. L. van der Want, Edo Vellenga*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

To investigate whether the type of programmed cell death of myelodysplastic erythroid cells depends on their cellular context, we performed studies on cells from patients with low-risk myelodysplastic syndromes. We compared erythroid cells (and their precursor cells) from the mononuclear cell fraction with those from the hematon fraction, which are compacted complexes of hematopoietic cells surrounded by their own micro-environment. In directly fixed materials, erythroblasts exhibited signs of autophagy with limited apoptosis (

Original languageEnglish
Pages (from-to)215-222.e2
Number of pages10
JournalExperimental Hematology
Volume43
Issue number3
DOIs
Publication statusPublished - Mar-2015

Keywords

  • MESENCHYMAL STROMAL CELLS
  • ACUTE MYELOID-LEUKEMIA
  • BONE-MARROW
  • ENHANCED AUTOPHAGY
  • STEM-CELL
  • MEGAKARYOCYTES
  • PRECURSORS
  • HEMATON
  • UNIT

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