ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

Angela Casini*, Guido Mastrobuoni, Wee Han Ang, Chiara Gabbiani, Giuseppe Pieraccini, Gloriano Moneti, Paul J. Dyson, Luigi Messori

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Electrospray ionization mass spectrometry allows a rapid characterisation of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compounds and horse heart cytochromec or hen egg white lysozyme. Specific information on the nature of the protein-bound metallic fragments and the extent of protein metallation was readily obtained.

Original languageEnglish
Pages (from-to)631-635
Number of pages5
JournalChemMedChem
Volume2
Issue number5
DOIs
Publication statusPublished - May-2007
Externally publishedYes

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