ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

Angela Casini; Guido Mastrobuoni; Wee Han Ang; Chiara Gabbiani; Giuseppe Pieraccini; Gloriano Moneti; Paul J. Dyson; Luigi Messori

doi:10.1002/cmdc.200600258

ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

Angela Casini^*, Guido Mastrobuoni, Wee Han Ang, Chiara Gabbiani, Giuseppe Pieraccini, Gloriano Moneti, Paul J. Dyson, Luigi Messori

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

88 Citations (Scopus)

Abstract

Electrospray ionization mass spectrometry allows a rapid characterisation of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compounds and horse heart cytochromec or hen egg white lysozyme. Specific information on the nature of the protein-bound metallic fragments and the extent of protein metallation was readily obtained.

Original language	English
Pages (from-to)	631-635
Number of pages	5
Journal	ChemMedChem
Volume	2
Issue number	5
DOIs	https://doi.org/10.1002/cmdc.200600258
Publication status	Published - May-2007
Externally published	Yes

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title = "ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes",

abstract = "Electrospray ionization mass spectrometry allows a rapid characterisation of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compounds and horse heart cytochromec or hen egg white lysozyme. Specific information on the nature of the protein-bound metallic fragments and the extent of protein metallation was readily obtained.",

author = "Angela Casini and Guido Mastrobuoni and Ang, {Wee Han} and Chiara Gabbiani and Giuseppe Pieraccini and Gloriano Moneti and Dyson, {Paul J.} and Luigi Messori",

year = "2007",

month = may,

doi = "10.1002/cmdc.200600258",

language = "English",

volume = "2",

pages = "631--635",

journal = "ChemMedChem",

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T1 - ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

AU - Casini, Angela

AU - Mastrobuoni, Guido

AU - Ang, Wee Han

AU - Gabbiani, Chiara

AU - Pieraccini, Giuseppe

AU - Moneti, Gloriano

AU - Dyson, Paul J.

AU - Messori, Luigi

PY - 2007/5

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AB - Electrospray ionization mass spectrometry allows a rapid characterisation of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compounds and horse heart cytochromec or hen egg white lysozyme. Specific information on the nature of the protein-bound metallic fragments and the extent of protein metallation was readily obtained.

U2 - 10.1002/cmdc.200600258

DO - 10.1002/cmdc.200600258

M3 - Article

VL - 2

SP - 631

EP - 635

JO - ChemMedChem

JF - ChemMedChem

SN - 1860-7179

IS - 5

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