Estrogen receptors alpha and beta and the risk of open-angle glaucoma

Simone de Voogd, Roger C. W. Wolfs, Nomdo M. Jansonius, Andre G. Uitterlinden, Huibert A. P. Pols, Albert Hofman, Paulus T. V. M. de Jong*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    22 Citations (Scopus)

    Abstract

    Objective: To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG).

    Methods: Participants 55 years and older from the population-based Rotterdam Study underwent, at baseline and at follow-up, the same ophthalmic examination, including visual field screening and stereo optic disc photography. A diagnosis of OAG was based on an algorithm using optic disc measures and visual field loss. Haplotypes of the ESR1 and ESR2 genes were determined.

    Results: We diagnosed incident OAG in 87 of 3842 participants (2.3%) at risk after a mean follow-up of 6.5 years. We could not detect any association with ESR1 haplotypes. Haplotype 1 of ESR2 showed a 3.6-fold (95% confidence interval, 1.4-9.2) higher risk of incident OAG in men. In women, no association was found between ESR2 and incident OAG.

    Conclusion: Polymorphisms in the ESR1 gene are unrelated to OAG, but ESR2 polymorphisms seem to lead to increased risk of OAG in men.

    Original languageEnglish
    Pages (from-to)110-114
    Number of pages5
    JournalARCHIVES OF OPHTHALMOLOGY
    Volume126
    Issue number1
    Publication statusPublished - Jan-2008

    Keywords

    • GENERAL ELDERLY POPULATION
    • VISUAL-FIELD LOSS
    • BEAVER-DAM EYE
    • ER-ALPHA
    • GENETIC RISK
    • POLYMORPHISMS
    • PREVALENCE
    • ROTTERDAM
    • ASSOCIATION
    • WOMEN

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