Estrogen receptors alpha and beta and the risk of open-angle glaucoma

Simone de Voogd; Roger C. W. Wolfs; Nomdo M. Jansonius; Andre G. Uitterlinden; Huibert A. P. Pols; Albert Hofman; Paulus T. V. M. de Jong

Estrogen receptors alpha and beta and the risk of open-angle glaucoma

Simone de Voogd, Roger C. W. Wolfs, Nomdo M. Jansonius, Andre G. Uitterlinden, Huibert A. P. Pols, Albert Hofman, Paulus T. V. M. de Jong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

Objective: To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG).

Methods: Participants 55 years and older from the population-based Rotterdam Study underwent, at baseline and at follow-up, the same ophthalmic examination, including visual field screening and stereo optic disc photography. A diagnosis of OAG was based on an algorithm using optic disc measures and visual field loss. Haplotypes of the ESR1 and ESR2 genes were determined.

Results: We diagnosed incident OAG in 87 of 3842 participants (2.3%) at risk after a mean follow-up of 6.5 years. We could not detect any association with ESR1 haplotypes. Haplotype 1 of ESR2 showed a 3.6-fold (95% confidence interval, 1.4-9.2) higher risk of incident OAG in men. In women, no association was found between ESR2 and incident OAG.

Conclusion: Polymorphisms in the ESR1 gene are unrelated to OAG, but ESR2 polymorphisms seem to lead to increased risk of OAG in men.

Original language	English
Pages (from-to)	110-114
Number of pages	5
Journal	ARCHIVES OF OPHTHALMOLOGY
Volume	126
Issue number	1
Publication status	Published - Jan-2008

Keywords

GENERAL ELDERLY POPULATION
VISUAL-FIELD LOSS
BEAVER-DAM EYE
ER-ALPHA
GENETIC RISK
POLYMORPHISMS
PREVALENCE
ROTTERDAM
ASSOCIATION
WOMEN

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Cite this

@article{847146eb60ea415fa7e7da1acc52b2c3,

title = "Estrogen receptors alpha and beta and the risk of open-angle glaucoma",

abstract = "Objective: To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG).Methods: Participants 55 years and older from the population-based Rotterdam Study underwent, at baseline and at follow-up, the same ophthalmic examination, including visual field screening and stereo optic disc photography. A diagnosis of OAG was based on an algorithm using optic disc measures and visual field loss. Haplotypes of the ESR1 and ESR2 genes were determined.Results: We diagnosed incident OAG in 87 of 3842 participants (2.3%) at risk after a mean follow-up of 6.5 years. We could not detect any association with ESR1 haplotypes. Haplotype 1 of ESR2 showed a 3.6-fold (95% confidence interval, 1.4-9.2) higher risk of incident OAG in men. In women, no association was found between ESR2 and incident OAG.Conclusion: Polymorphisms in the ESR1 gene are unrelated to OAG, but ESR2 polymorphisms seem to lead to increased risk of OAG in men.",

keywords = "GENERAL ELDERLY POPULATION, VISUAL-FIELD LOSS, BEAVER-DAM EYE, ER-ALPHA, GENETIC RISK, POLYMORPHISMS, PREVALENCE, ROTTERDAM, ASSOCIATION, WOMEN",

author = "{de Voogd}, Simone and Wolfs, {Roger C. W.} and Jansonius, {Nomdo M.} and Uitterlinden, {Andre G.} and Pols, {Huibert A. P.} and Albert Hofman and {de Jong}, {Paulus T. V. M.}",

year = "2008",

month = jan,

language = "English",

volume = "126",

pages = "110--114",

journal = "ARCHIVES OF OPHTHALMOLOGY",

issn = "0003-9950",

publisher = "AMER MEDICAL ASSOC",

number = "1",

}

TY - JOUR

T1 - Estrogen receptors alpha and beta and the risk of open-angle glaucoma

AU - de Voogd, Simone

AU - Wolfs, Roger C. W.

AU - Jansonius, Nomdo M.

AU - Uitterlinden, Andre G.

AU - Pols, Huibert A. P.

AU - Hofman, Albert

AU - de Jong, Paulus T. V. M.

PY - 2008/1

Y1 - 2008/1

N2 - Objective: To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG).Methods: Participants 55 years and older from the population-based Rotterdam Study underwent, at baseline and at follow-up, the same ophthalmic examination, including visual field screening and stereo optic disc photography. A diagnosis of OAG was based on an algorithm using optic disc measures and visual field loss. Haplotypes of the ESR1 and ESR2 genes were determined.Results: We diagnosed incident OAG in 87 of 3842 participants (2.3%) at risk after a mean follow-up of 6.5 years. We could not detect any association with ESR1 haplotypes. Haplotype 1 of ESR2 showed a 3.6-fold (95% confidence interval, 1.4-9.2) higher risk of incident OAG in men. In women, no association was found between ESR2 and incident OAG.Conclusion: Polymorphisms in the ESR1 gene are unrelated to OAG, but ESR2 polymorphisms seem to lead to increased risk of OAG in men.

AB - Objective: To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG).Methods: Participants 55 years and older from the population-based Rotterdam Study underwent, at baseline and at follow-up, the same ophthalmic examination, including visual field screening and stereo optic disc photography. A diagnosis of OAG was based on an algorithm using optic disc measures and visual field loss. Haplotypes of the ESR1 and ESR2 genes were determined.Results: We diagnosed incident OAG in 87 of 3842 participants (2.3%) at risk after a mean follow-up of 6.5 years. We could not detect any association with ESR1 haplotypes. Haplotype 1 of ESR2 showed a 3.6-fold (95% confidence interval, 1.4-9.2) higher risk of incident OAG in men. In women, no association was found between ESR2 and incident OAG.Conclusion: Polymorphisms in the ESR1 gene are unrelated to OAG, but ESR2 polymorphisms seem to lead to increased risk of OAG in men.

KW - GENERAL ELDERLY POPULATION

KW - VISUAL-FIELD LOSS

KW - BEAVER-DAM EYE

KW - ER-ALPHA

KW - GENETIC RISK

KW - POLYMORPHISMS

KW - PREVALENCE

KW - ROTTERDAM

KW - ASSOCIATION

KW - WOMEN

M3 - Article

VL - 126

SP - 110

EP - 114

JO - ARCHIVES OF OPHTHALMOLOGY

JF - ARCHIVES OF OPHTHALMOLOGY

SN - 0003-9950

IS - 1

ER -