EVALUATION OF A CYTOLOGICAL SCORING SYSTEM FOR PREDICTING HISTOLOGICAL GRADE AND DISEASE-FREE SURVIVAL IN PRIMARY BREAST-CANCER

H DEGRAAF; P WILLEMSE; BE LADDE; HA VANDENBERGEN; M KREBBER; T TJABBES; WJ SLUITER

EVALUATION OF A CYTOLOGICAL SCORING SYSTEM FOR PREDICTING HISTOLOGICAL GRADE AND DISEASE-FREE SURVIVAL IN PRIMARY BREAST-CANCER

H DEGRAAF^*, P WILLEMSE, BE LADDE, HA VANDENBERGEN, M KREBBER, T TJABBES, WJ SLUITER

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A simple cytological scoring system was evaluated as a method of predicting histological grade and disease-free survival in 79 patients with primary breast cancer. The mitotic activity index and oestrogen receptor status were also assessed for their predictive value. The concordance between cytological scores and histological grades was good (80%) for low-grade lesions, but poor (45%) for high-grade lesions. Similar results were found using the mitotic activity index as a prognostic indicator. Cytological grading was not found to be an independent prognostic indicator after a median follow up of 8 years.

Original language	English
Pages (from-to)	294-300
Number of pages	7
Journal	Cytopathology
Volume	5
Issue number	5
Publication status	Published - Oct-1994

Keywords

BREAST CANCER
CYTOLOGY
HISTOLOGICAL GRADE
MITOTIC ACTIVITY INDEX
ESTROGEN RECEPTOR STATUS
PROGNOSIS
DISEASE-FREE SURVIVAL
ASPIRATION CYTOLOGY
NEEDLE ASPIRATION
PROGNOSTIC VALUE
MORPHOMETRY
SPECIMENS
CARCINOMAS
DIAGNOSIS
LESIONS
BENIGN

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title = "EVALUATION OF A CYTOLOGICAL SCORING SYSTEM FOR PREDICTING HISTOLOGICAL GRADE AND DISEASE-FREE SURVIVAL IN PRIMARY BREAST-CANCER",

abstract = "A simple cytological scoring system was evaluated as a method of predicting histological grade and disease-free survival in 79 patients with primary breast cancer. The mitotic activity index and oestrogen receptor status were also assessed for their predictive value. The concordance between cytological scores and histological grades was good (80%) for low-grade lesions, but poor (45%) for high-grade lesions. Similar results were found using the mitotic activity index as a prognostic indicator. Cytological grading was not found to be an independent prognostic indicator after a median follow up of 8 years.",

keywords = "BREAST CANCER, CYTOLOGY, HISTOLOGICAL GRADE, MITOTIC ACTIVITY INDEX, ESTROGEN RECEPTOR STATUS, PROGNOSIS, DISEASE-FREE SURVIVAL, ASPIRATION CYTOLOGY, NEEDLE ASPIRATION, PROGNOSTIC VALUE, MORPHOMETRY, SPECIMENS, CARCINOMAS, DIAGNOSIS, LESIONS, BENIGN",

author = "H DEGRAAF and P WILLEMSE and BE LADDE and HA VANDENBERGEN and M KREBBER and T TJABBES and WJ SLUITER",

year = "1994",

month = oct,

language = "English",

volume = "5",

pages = "294--300",

journal = "Cytopathology",

issn = "0956-5507",

number = "5",

}

TY - JOUR

T1 - EVALUATION OF A CYTOLOGICAL SCORING SYSTEM FOR PREDICTING HISTOLOGICAL GRADE AND DISEASE-FREE SURVIVAL IN PRIMARY BREAST-CANCER

AU - DEGRAAF, H

AU - WILLEMSE, P

AU - LADDE, BE

AU - VANDENBERGEN, HA

AU - KREBBER, M

AU - TJABBES, T

AU - SLUITER, WJ

PY - 1994/10

Y1 - 1994/10

N2 - A simple cytological scoring system was evaluated as a method of predicting histological grade and disease-free survival in 79 patients with primary breast cancer. The mitotic activity index and oestrogen receptor status were also assessed for their predictive value. The concordance between cytological scores and histological grades was good (80%) for low-grade lesions, but poor (45%) for high-grade lesions. Similar results were found using the mitotic activity index as a prognostic indicator. Cytological grading was not found to be an independent prognostic indicator after a median follow up of 8 years.

AB - A simple cytological scoring system was evaluated as a method of predicting histological grade and disease-free survival in 79 patients with primary breast cancer. The mitotic activity index and oestrogen receptor status were also assessed for their predictive value. The concordance between cytological scores and histological grades was good (80%) for low-grade lesions, but poor (45%) for high-grade lesions. Similar results were found using the mitotic activity index as a prognostic indicator. Cytological grading was not found to be an independent prognostic indicator after a median follow up of 8 years.

KW - BREAST CANCER

KW - CYTOLOGY

KW - HISTOLOGICAL GRADE

KW - MITOTIC ACTIVITY INDEX

KW - ESTROGEN RECEPTOR STATUS

KW - PROGNOSIS

KW - DISEASE-FREE SURVIVAL

KW - ASPIRATION CYTOLOGY

KW - NEEDLE ASPIRATION

KW - PROGNOSTIC VALUE

KW - MORPHOMETRY

KW - SPECIMENS

KW - CARCINOMAS

KW - DIAGNOSIS

KW - LESIONS

KW - BENIGN

M3 - Article

SN - 0956-5507

VL - 5

SP - 294

EP - 300

JO - Cytopathology

JF - Cytopathology

IS - 5

ER -

EVALUATION OF A CYTOLOGICAL SCORING SYSTEM FOR PREDICTING HISTOLOGICAL GRADE AND DISEASE-FREE SURVIVAL IN PRIMARY BREAST-CANCER

Abstract

Keywords

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