Evaluation of BACE1 silencing as a therapy against Alzheimer disease: implications for lipid metabolism and inflammatory response

Javier Villamil Ortiz

    Research output: ThesisThesis fully internal (DIV)

    967 Downloads (Pure)

    Abstract

    Our results show, for the first time, that BACE1 protein levels are not only related to proteins aggregations but also control of pro-inflammatory response through the restoration of phospholipid composition which downregulated specific proinflammatory molecules at the hippocampus promoting cellular homeostasis and cognitive function recovery AD model mice. Those results showed that endogenous lipids are important mediators of Alzheimer disease not only because they are involved in all phases of inflammation, but also involved in the regulation and fine-tuning of its course and cessation.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Eggen, Bart, Supervisor
    • Boddeke, Erik, Supervisor
    • Cardona Gómez, G.P., Co-supervisor, External person
    • Bakker, Barbara, Assessment committee
    • Foijer, Floris, Assessment committee
    • Kirchhoff, F., Assessment committee, External person
    Award date22-Oct-2019
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-034-2125-4
    Electronic ISBNs978-94-034-2124-7
    DOIs
    Publication statusPublished - 2019

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